Technology Process of 2,2,2-trifluoro-1-[1-di(4-fluorophenyl)methylindol-5-yl]-1-ethanone
There total 3 articles about 2,2,2-trifluoro-1-[1-di(4-fluorophenyl)methylindol-5-yl]-1-ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 1h;
DOI:10.3987/COM-99-8480
- Guidance literature:
-
1-[bis-(4-fluoro-phenyl)-methyl]-5-bromo-1H-indole;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.166667h;
With
copper(I) bromide dimethylsulfide complex;
at -70 - -40 ℃;
for 1h;
trifluoroacetic acid;
at -78 ℃;
for 0.5h;
DOI:10.3987/COM-99-8480
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydride,; t-BuLi / tetrahydrofuran; pentane / 0.42 h / -78 °C
1.2: 57 percent / 0.5 h / -78 °C
2.1: 32 percent / t-BuOK / dimethylformamide / 1 h / 0 °C
With
potassium tert-butylate; tert.-butyl lithium; potassium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; pentane;
1.1: Metallation / 1.2: Acylation / 2.1: Alkylation;
DOI:10.3987/COM-99-8480