[2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane

Base Information

• Chemical Name: [2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane
• CAS No.: 1418287-36-1
• Molecular Formula: C₁₈H₃₂O₃Si
• Molecular Weight: 324.536
• Mol file: 1418287-36-1.mol

Synonyms:[2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane

Chemical Property of [2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane

There total 1 articles about [2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(tert-butoxy)phenol (2460-87-9) + 2-(tert-butyldimethylsilyloxy)ethanol (102229-10-7) → [2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane (1418287-36-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃;

Reference yield: 93.0%

[2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane (1418287-36-1) → 2-(4-tert-butoxyphenoxy)ethanol (1418287-35-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; 2-methyltetrahydrofuran; at 60 ℃; for 4h;

Reference yield:

[2-(4-tert-butoxyphenoxy)ethoxy](tert-butyl)dimethylsilane (1418287-36-1) → 4-(3-ethoxyphenyl)-1-{2-[4-(pyridin-3-yloxy)phenoxy]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid trifluoroacetate

Guidance literature:

Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran; 2-methyltetrahydrofuran / 4 h / 60 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 3 h / 20 °C

3.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / 3 h / 20 °C

5.1: caesium carbonate; copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione / 1-methyl-pyrrolidin-2-one / 120 °C / Inert atmosphere

5.2: 20 °C

With potassium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 2,2,6,6-tetramethylheptane-3,5-dione; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; caesium carbonate; triphenylphosphine; trifluoroacetic acid; copper(l) chloride; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; toluene; 2.1: |Mitsunobu Displacement;

upstream raw materials:

4-(tert-butoxy)phenol

2-(tert-butyldimethylsilyloxy)ethanol

Downstream raw materials:

methyl 1-[2-(4-tert-butoxyphenoxy)ethyl]-4-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

methyl 1-[2-(4-tert-butoxyphenoxy)ethyl]-4-(3-ethoxyphenyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

methyl 4-(3-ethoxyphenyl)-1-[2-(4-hydroxyphenoxy)ethyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

2-(4-tert-butoxyphenoxy)ethanol

Refernces