5,6-BIS-BENZYLOXY-4,7-DIMETHYLINDOLE

Base Information

• Chemical Name: 5,6-BIS-BENZYLOXY-4,7-DIMETHYLINDOLE
• CAS No.: 97073-53-5
• Molecular Formula: C24H23 N O2
• Molecular Weight: 357.452
• Hs Code.: 2933990090
• Mol file: 97073-53-5.mol

Synonyms:5,6-BIS-BENZYLOXY-4,7-DIMETHYLINDOLE

Chemical Property of 5,6-BIS-BENZYLOXY-4,7-DIMETHYLINDOLE

Chemical Property:

• Vapor Pressure: 4.62E-11mmHg at 25°C
• Refractive Index: 1.647
• Boiling Point: 537°C at 760 mmHg
• Flash Point: 189°C
• PSA: 34.25000
• Density: 1.176g/cm³
• LogP: 5.94270

Purity/Quality:

95+% ^*data from raw suppliers

5,6-BIS-BENZYLOXY-4,7-DIMETHYLINDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-BIS-BENZYLOXY-4,7-DIMETHYLINDOLE

There total 6 articles about 5,6-BIS-BENZYLOXY-4,7-DIMETHYLINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,5-bis(benzyloxy)-3,6-dimethyl-2,β-dinitrostyrene (97073-51-3) → 5,6-bis(benzyloxy)-4,7-dimethylindole (97073-53-5)

Guidance literature:

With silica gel; iron; In acetic acid; toluene; for 1h; Heating;

DOI:10.1021/jm00147a027

Reference yield:

3,6-Dimethylcatechol (2785-78-6) → 5,6-bis(benzyloxy)-4,7-dimethylindole (97073-53-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 64 percent / AlCl₃ / benzene / 0.33 h / 60 °C

2: 92 percent / KI, K₂CO₃ / acetone / 7 h / Heating

3: 64 percent / NH₄OAc / acetic acid / 1.5 h / Heating

4: 48 percent / Cu(NO₃)2*3H₂O / acetic anhydride / 1.25 h / 60 - 65 °C

5: 90 percent / silica gel, Fe / acetic acid; toluene / 1 h / Heating

With aluminium trichloride; ammonium acetate; silica gel; iron; potassium carbonate; copper(II) nitrate; potassium iodide; In acetic anhydride; acetic acid; acetone; toluene; benzene;

DOI:10.1021/jm00147a027

Reference yield:

benzyl chloride (100-44-7) → 5,6-bis(benzyloxy)-4,7-dimethylindole (97073-53-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / KI, K₂CO₃ / acetone / 7 h / Heating

2: 64 percent / NH₄OAc / acetic acid / 1.5 h / Heating

3: 48 percent / Cu(NO₃)2*3H₂O / acetic anhydride / 1.25 h / 60 - 65 °C

4: 90 percent / silica gel, Fe / acetic acid; toluene / 1 h / Heating

With ammonium acetate; silica gel; iron; potassium carbonate; copper(II) nitrate; potassium iodide; In acetic anhydride; acetic acid; acetone; toluene;

DOI:10.1021/jm00147a027

upstream raw materials:

4,5-bis(benzyloxy)-3,6-dimethyl-2,β-dinitrostyrene

3,6-Dimethylcatechol

benzyl chloride

3,4-dihydroxy-2,5-dimethylbenzaldehyde

Downstream raw materials:

(5,6-Bis-benzyloxy-4,7-dimethyl-1H-indol-3-ylmethyl)-dimethyl-amine

Refernces