allyl (4-(trifluoromethyl)phenyl)carbamate

Base Information

• Chemical Name: allyl (4-(trifluoromethyl)phenyl)carbamate
• CAS No.: 23794-82-3
• Molecular Formula: C₁₁H₁₀F₃NO₂
• Molecular Weight: 245.201
• Mol file: 23794-82-3.mol

Synonyms:allyl (4-(trifluoromethyl)phenyl)carbamate

Chemical Property of allyl (4-(trifluoromethyl)phenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of allyl (4-(trifluoromethyl)phenyl)carbamate

There total 3 articles about allyl (4-(trifluoromethyl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-trifluoromethylphenylamine (455-14-1) + Allyl chloroformate (2937-50-0) → allyl (4-(trifluoromethyl)phenyl)carbamate (23794-82-3)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02780

Reference yield: 63.0%

allyl carbamate (2114-11-6) + p-trifluoromethylphenyl bromide (402-43-7) → allyl (4-(trifluoromethyl)phenyl)carbamate (23794-82-3)

Guidance literature:

allyl carbamate; With tris[2-phenylpyridinato-C₂,N]iridium(III); nickel(II) bromide dimethoxyethane; 4,4'-Dimethoxy-2,2'-bipyridin; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

p-trifluoromethylphenyl bromide; In N,N-dimethyl-formamide; at 35 ℃; for 18h; Sealed tube; Irradiation;

DOI:10.1002/chem.202000052

Reference yield:

allyl alcohol (107-18-6) + p-trifluoromethyl-phenylisocyanate (1548-13-6) → allyl (4-(trifluoromethyl)phenyl)carbamate (23794-82-3)

Guidance literature:

With triethylamine; In benzene;

upstream raw materials:

allyl alcohol

p-trifluoromethyl-phenylisocyanate

4-trifluoromethylphenylamine

Allyl chloroformate

Downstream raw materials:

4-methyl-3-(4-trifluoromethyl-phenyl)-oxazolidin-2-one

Refernces

• 1、 Escobar, Randolph A.,Johannes, Jeffrey W.. "A Unified and Practical Method for Carbon–Heteroatom Cross-Coupling using Nickel/Photo Dual Catalysis". supporting information. . Retrieved 2020/04/17.