P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide

Base Information

• Chemical Name: P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide
• CAS No.: 62369-76-0
• Molecular Formula: C₂₀H₂₀NOP
• Molecular Weight: 321.359
• Mol file: 62369-76-0.mol

Synonyms:P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide

Chemical Property of P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide

There total 12 articles about P-diphenyl(N-benzyl-N-methyl)-λ⁵-phosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

chloro-diphenylphosphine (1079-66-9,74391-44-9) + benzyl-methyl-amine (103-67-3) → P-diphenyl(N-benzyl-N-methyl)-λ5-phosphinamide (62369-76-0)

Guidance literature:

chloro-diphenylphosphine; benzyl-methyl-amine; With triethylamine; In toluene; at -30 ℃; for 4h;

With dihydrogen peroxide; In toluene; for 1h; Further stages.;

DOI:10.1021/ol015716t

Reference yield: 77.0%

benzyl-methyl-amine (103-67-3) + Diphenylphosphine oxide (4559-70-0) → P-diphenyl(N-benzyl-N-methyl)-λ5-phosphinamide (62369-76-0)

Guidance literature:

With potassium iodide; In ethanol; at 20 ℃; for 4h; Electrolysis;

DOI:10.1039/c7gc01989k

Reference yield:

Methylbenzylamino-diphenylphosphin (20685-06-7) → P-diphenyl(N-benzyl-N-methyl)-λ5-phosphinamide (62369-76-0)

Guidance literature:

With 30percent H₂O₂; In toluene; at -30 ℃; for 1h;

DOI:10.1021/jo025587+

upstream raw materials:

N-benzyl-P,P-diphenylphosphinic amide

methyl iodide

chloro-diphenylphosphine

benzyl-methyl-amine

Downstream raw materials:

diphenylphosphinic acid N-methyl-(S)-α-methylbenzylamide

N-methyl-P,P-diphenyl-N-[(1R)-1-phenylethyl]phosphinic amide

N-[(1R,2R)-2-hydroxy-1-phenylbut-3-en-1-yl]-N-methyl-P,P-diphenylphosphinic amide

N-[(1R,2S)-2-hydroxy-1-phenylbut-3-en-1-yl]-N-methyl-P,P-diphenylphosphinic amide

Refernces

• 1、 Wang, Yukang,Qian, Peng,Su, Ji-Hu,Li, Yanan,Bi, Meixiang,Zha, Zhenggen,Wang, Zhiyong. "Efficient electrosynthesis of phosphinic amides via oxidative cross-coupling between N-H/P-H". supporting information. p. 4769 - 4773. Retrieved 2017/10/23.
• 2、 Fernandez, Ignacio,Ortiz, Fernando Lopez,Velazquez, Amador Menendez,Granda, Santiago Garcia. "Regio- and diastereoselective preparation of tetrahydrobenzo[c]-1-aza-2lambda(5)-phospholes through dearomatization cyclization of lithiated N-benzyl-N-alkyl(diphenyl)phosphinamides. Synthesis of gamma-(N-alkylamino)phosphinic acids.". . p. 3852 - 3860. Retrieved 2007/10/03.