C₁₀H₁₁N

Base Information

• Chemical Name: C₁₀H₁₁N
• CAS No.: 1179523-32-0
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.204
• Mol file: 1179523-32-0.mol

Synonyms:C₁₀H₁₁N

Chemical Property of C₁₀H₁₁N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₁N

There total 3 articles about C₁₀H₁₁N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C27H35N (1376191-20-6) → C10H11N (1179523-32-0) + (R)-1-phenylundeca-1,2-diene (27694-89-9) + (S)-1-phenylundeca-1,2-diene (27694-89-9)

Guidance literature:

With zinc(II) iodide; In toluene; at 120 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol300717e

Reference yield: 57.0%

carbon monoxide (201230-82-2) + (1S)-1-phenyl-2-propen-1-amine (244092-75-9) → C10H11N (1179523-32-0)

Guidance literature:

With hydrogen; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); rhodium(I) dicarbonyl acetylacetonate; In chloroform; at 50 ℃; under 22502.3 Torr; optical yield given as %ee; Autoclave;

DOI:10.1055/s-0029-1217165

Reference yield:

(S)-2-phenylpyrrolidine (1006-64-0,56523-47-8,56586-11-9,59347-91-0) → C10H11N (1179523-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc(II) iodide / toluene / 10 h / 90 °C / Inert atmosphere

2: zinc(II) iodide / toluene / 3 h / 120 °C / Inert atmosphere

With zinc(II) iodide; In toluene;

DOI:10.1021/ol300717e

upstream raw materials:

carbon monoxide

(1S)-1-phenyl-2-propen-1-amine

C₂₇H₃₅N

(S)-2-phenylpyrrolidine

Downstream raw materials:

(S)-2-phenylpyrrolidine

C₂₇H₃₅N

Refernces

• 1、 Dübon, Pierre,Farwick, Andreas,Helmchen, Günter. "Enantioselective syntheses of 2-substituted pyrrolidines from allylamines by domino hydroformylation-condensation: Short syntheses of (S)-nicotine and the alkaloid 225C". experimental part. p. 1413 - 1416. Retrieved 2009/10/23.