4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline

Base Information

• Chemical Name: 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline
• CAS No.: 1440060-55-8
• Molecular Formula: C₂₁H₁₃Cl₂F₂NO₂
• Molecular Weight: 420.243
• Mol file: 1440060-55-8.mol

Synonyms:4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline

Chemical Property of 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline

There total 6 articles about 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C21H14Cl3F2NO2 (1440059-75-5) → 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline (1440060-55-8)

Guidance literature:

With sodium hydroxide; In methanol; at 50 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c3nj00032j

Reference yield:

3,4'-Dichlorobiphenyl ether (6842-62-2) → 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline (1440060-55-8)

Guidance literature:

Multi-step reaction with 6 steps

1: aluminum (III) chloride / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride / ethanol / 5 h / Reflux; Inert atmosphere

3: sodium tetrahydroborate; iodine / tetrahydrofuran / 7.5 h / 0 °C / Reflux; Inert atmosphere

4: triethylamine / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

5: thionyl chloride / toluene / 3 h / 80 °C / Inert atmosphere

6: sodium hydroxide / methanol / 1 h / 50 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; iodine; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 1: |Friedel-Crafts Acylation;

DOI:10.1039/c3nj00032j

Reference yield:

C16H13Cl2NO4 (1440061-93-7) → 4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline (1440060-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; iodine / tetrahydrofuran / 7.5 h / 0 °C / Reflux; Inert atmosphere

2: triethylamine / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

3: thionyl chloride / toluene / 3 h / 80 °C / Inert atmosphere

4: sodium hydroxide / methanol / 1 h / 50 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; iodine; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; toluene;

DOI:10.1039/c3nj00032j

upstream raw materials:

C₁₆H₁₃Cl₂NO₄

C₁₆H₁₂Cl₂O₄

3,4'-Dichlorobiphenyl ether

C₂₁H₁₄Cl₃F₂NO₂

Refernces