1-Azido-4-chlorobenzene solution

Base Information

• Chemical Name: 1-Azido-4-chlorobenzene solution
• CAS No.: 3296-05-7
• Molecular Formula: C6H4 Cl N3
• Molecular Weight: 153.571
• Hs Code.: 2929909090
• Mol file: 3296-05-7.mol

Synonyms:1-Azido-4-chlorobenzene;4-Chlorophenyl azide; p-Azidobenzochloride; p-Azidochlorobenzene;p-Chloroazidobenzene; p-Chlorophenyl azide

Chemical Property of 1-Azido-4-chlorobenzene solution

Chemical Property:

• Melting Point: 20°C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 252.42°C (rough estimate)
• Flash Point: -30℃
• PSA: 49.75000
• Density: 1.2634
• LogP: 2.73456
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Azido-4-chlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 1210408
• Hazard Codes: F,Xn
• Statements: 11-22-38-43
• Safety Statements: 16-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1-Azido-4-chlorobenzene solution

There total 35 articles about 1-Azido-4-chlorobenzene solution which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-chloro-aniline (106-47-8) → 1-azido-4-chlorobenzene (3296-05-7)

Guidance literature:

4-chloro-aniline; With sulfuric acid; trifluoroacetic acid; sodium nitrite; In water; at 15 - 18 ℃; for 0.5h;

With sodium azide; In water; for 1.5h;

Reference yield: 90.0%

bromochlorobenzene (106-39-8) → 1-azido-4-chlorobenzene (3296-05-7)

Guidance literature:

With copper(l) iodide; sodium azide; L-proline; sodium hydroxide; In ethanol; at 95 ℃; for 24h;

DOI:10.1039/b400878b

Reference yield: 90.0%

4-Chlorophenylboronic acid (1679-18-1) → 1-azido-4-chlorobenzene (3296-05-7)

Guidance literature:

With trimethylsilylazide; tetrabutyl ammonium fluoride; copper(l) chloride; In tetrahydrofuran; methanol; for 4h; Reflux; In air;

DOI:10.1002/chem.201000971

upstream raw materials:

benzenesulfonamide

p-chlorobenzenediazonium chloride

4-chlorophenyldiazonium salt

1-chloro-4-nitroso-benzene

Downstream raw materials:

1,3'-bis-(4-chloro-phenyl)-5,5'-bis-(1-hydroxy-cyclohexyl)-1H,3'H-[4,4']bi[1,2,3]triazolyl

N-p-chlorophenyltriphenylphosphinimine

1-(4-chloro-phenyl)-7a-morpholin-4-yl-3a,4,5,6,7,7a-hexahydro-1H-4,7-methano-benzo[1,2,3]triazole

4-chloro-2-(tetrahydrothiophen-2-yl)aniline

Refernces

• 1、 ?e?me, Mustafa,?ahin, ?rfan,Tümer, Ferhan,Yüce, Neslihan. "Discovery of new 1,4-disubstituted 1,2,3-triazoles: in silico ADME profiling, molecular docking and biological evaluation studies". . . Retrieved 2022/01/31.
• 2、 Bhaskar, Kuthati,Hu, Anren,Hung, Sung-Jen,Raju, Atcha Krishnam,Rao, Vankadari Srinivasa,Reddy, Nadipolla Naresh,Reddy, Puchakayala Muralidhar,Rohini, Rondla,Sanjeev, Ananthula,Swamy, Merugu Kumara. "Synthesis and rational design of new appended 1,2,3-triazole-uracil ensembles as promising anti-tumor agents via in silico vegfr-2 transferase inhibition". . . Retrieved 2021/05/29.