Anisole, 3-isopropyl-5-methyl- (7CI)

Base Information

• Chemical Name: Anisole, 3-isopropyl-5-methyl- (7CI)
• CAS No.: 91967-53-2
• Molecular Formula: C₁₁H₁₆O
• Molecular Weight: 164.247
• Mol file: 91967-53-2.mol

Synonyms:Anisole,3-isopropyl-5-methyl- (7CI)

Chemical Property of Anisole, 3-isopropyl-5-methyl- (7CI)

Chemical Property:

• PSA: 9.23000
• LogP: 3.12700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Anisole, 3-isopropyl-5-methyl- (7CI)

There total 2 articles about Anisole, 3-isopropyl-5-methyl- (7CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-isopropyl-5-methylphenol (3228-03-3) + dimethyl sulfate (77-78-1) → 5-isopropyl-3-methylanisole (91967-53-2)

Guidance literature:

With sodium hydroxide; for 1.5h; Heating;

DOI:10.1021/ol051929x

Reference yield:

→ 5-isopropyl-3-methylanisole (91967-53-2)

Guidance literature:

durch Desulfurierung v. 5-Methoxy-3.7-dimethyl-benzothiophen an Raney-Nickel nach Meth. Bl. 1962, 1711;

Reference yield:

5-isopropyl-3-methylanisole (91967-53-2) → 2-benzyl-1-isopropyl-5-methoxy-3-methylbenzene

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / N-bromosuccinimide / acetonitrile / 0 - 20 °C

2: 80 percent / K₃PO₄; Pd(OAc)2; SPhos / dimethylformamide; tetrahydrofuran / 4.5 h / 100 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate; N-Bromosuccinimide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki-Miyaura reaction;

DOI:10.1021/ol051929x

upstream raw materials:

3-isopropyl-5-methylphenol

dimethyl sulfate

Refernces