3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine hydrochloride

Base Information

• Chemical Name: 3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine hydrochloride
• CAS No.: 96300-88-8
• Molecular Formula: C9H13 N O2 . Cl H
• Molecular Weight: 203.669
• Hs Code.: 2933399090
• UNII: T12J3Y7ODO
• Mol file: 96300-88-8.mol

Synonyms:96300-88-8;3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine hydrochloride;T12J3Y7ODO;3,5-DIMETHYL-4-METHOXY-2-PYRIDINE;(4-Methoxy-3,5-dimethylpyridin-2-yl)methanol Hydrochloride;(4-methoxy-3,5-dimethylpyridin-2-yl)methanol;hydrochloride;2-Pyridinemethanol, 4-methoxy-3,5-dimethyl-, hydrochloride;2-Pyridinemethanol, 4-methoxy-3,5-dimethyl-, hydrochloride (1:1);UNII-T12J3Y7ODO;SCHEMBL3247161;QDZLOVCSHPNYIF-UHFFFAOYSA-N;(4-Methoxy-3,5-dimethylpyridin-2-yl)methanolHydrochloride;2-hydroxymethyl-3,5-dimethyl-4-methoxy pyridine hydrochloride

Chemical Property of 3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine hydrochloride

Chemical Property:

• PSA: 42.35000
• LogP: 2.00130
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 203.0713064
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

98% ^*data from raw suppliers

(4-Methoxy-3,5-dimethylpyridin-2-yl)methanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C(=C1OC)C)CO.Cl
• Uses: (4-Methoxy-3,5-dimethylpyridin-2-yl)methanol Hydrochloride has been used in the preparation of omeprazole intermediates.

Technology Process of 3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine hydrochloride

There total 4 articles about 3,5-Dimethyl-2-hydroxymethyl-4-methoxy-pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2,3,5-trimethylpyridine 1-oxide (109371-20-2) → 2-Hydroxymethyl-4-methoxy-3,5-dimethylpyridine hydrochloride (96300-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide

2: acetic acid / methanol; toluene

3: sodium hydroxide / methanol

With acetic acid; sodium hydroxide; In methanol; toluene;

DOI:10.14233/ajchem.2013.14818

Reference yield:

4-methoxy-2,3,5-trimethylpyridine 1-oxide (86604-80-0) → 2-Hydroxymethyl-4-methoxy-3,5-dimethylpyridine hydrochloride (96300-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol; toluene

2: sodium hydroxide / methanol

With acetic acid; sodium hydroxide; In methanol; toluene;

DOI:10.14233/ajchem.2013.14818

Reference yield:

(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl acetate (91219-90-8) → 2-Hydroxymethyl-4-methoxy-3,5-dimethylpyridine hydrochloride (96300-88-8)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.14233/ajchem.2013.14818

upstream raw materials:

4-chloro-2,3,5-trimethylpyridine 1-oxide

4-methoxy-2,3,5-trimethylpyridine 1-oxide

(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl acetate

Downstream raw materials:

2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Refernces

• 1、 -. "Fluoroalkoxy substituted benzimidazoles useful as gastric acid secretion inhibitors". . . Retrieved 2008/06/13.
• 2、 -. "2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects". . . Retrieved 2008/06/13.