1,2-CYCLOPROPANEDICARBOXYLIC ACID BIS [(1R, 2S, 5R)]-5-METHYL-2-(1-METHYLETHYL)

Base Information Edit

Chemical Name:1,2-CYCLOPROPANEDICARBOXYLIC ACID BIS [(1R, 2S, 5R)]-5-METHYL-2-(1-METHYLETHYL)
CAS No.:96149-00-7
Molecular Formula:C25H42 O4
Molecular Weight:406.606
Hs Code.:
Mol file:96149-00-7.mol

Synonyms:1,2-Cyclopropanedicarboxylicacid, bis[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester, (1S,2S)-(9CI); 1,2-Cyclopropanedicarboxylic acid,bis[5-methyl-2-(1-methylethyl)cyclohexyl] ester, [1R-[1a[1S*,2S*(1R*,2S*,5R*)],2b,5a]]-

Suppliers and Price of 1,2-CYCLOPROPANEDICARBOXYLIC ACID BIS [(1R, 2S, 5R)]-5-METHYL-2-(1-METHYLETHYL)

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dimenthyl(1S,2S)-Cyclopropane-1,2-dicarboxylate
500mg
$ 160.00

ChemScene
(1S,2S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)cyclopropane-1,2-dicarboxylate
1g
$ 319.00

American Custom Chemicals Corporation
(1S,2S)-BIS-((1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXYL)CYCLOPROPANE-1,2-DICARBOXYLATE 95.00%
5MG
$ 501.74

Total 7 raw suppliers

Chemical Property of 1,2-CYCLOPROPANEDICARBOXYLIC ACID BIS [(1R, 2S, 5R)]-5-METHYL-2-(1-METHYLETHYL) Edit

Chemical Property:

PSA：80.26000
LogP:3.27950

Purity/Quality:

≥95% ^*data from raw suppliers

Dimenthyl(1S,2S)-Cyclopropane-1,2-dicarboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Dimenthyl (1S,2S)-Cyclopropane-1,2-dicarboxylate was used in the synthesis of Callipeltoside A, an inhibitor of the proliferation of KB and P388 cells.

Technology Process of 1,2-CYCLOPROPANEDICARBOXYLIC ACID BIS [(1R, 2S, 5R)]-5-METHYL-2-(1-METHYLETHYL)

There total 7 articles about 1,2-CYCLOPROPANEDICARBOXYLIC ACID BIS [(1R, 2S, 5R)]-5-METHYL-2-(1-METHYLETHYL) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 74-97-5
chlorobromomethane

: 34212-59-4,96149-05-2
bis(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl butanedioate

: 96149-00-7
(1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

Guidance literature:: With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1002/1521-3773(20020301)41

Reference yield:

: 2216-51-5
(-)-menthol

: 96149-00-7
(1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 24 h / Heating / reflux

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 2 h / -78 °C

2.3: 0.5 h

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; toluene;

Reference yield:

: 2216-51-5
(-)-menthol

: 96149-00-7
(1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / concd. HCl / 30 h / 85 - 90 °C

2: 1.) lithium 2,2,6,6-tetramethylpiperidide / 1.) THF, -78 deg C, 1 h; 2.) -78 deg C, 3h

With hydrogenchloride; 2,2,6,6-tetramethylpiperidinyl-lithium;
DOI:10.1021/ja00297a048