2-Amino-4-piperidino-6-methylpyrimidine

Base Information

• Chemical Name: 2-Amino-4-piperidino-6-methylpyrimidine
• CAS No.: 91717-22-5
• Molecular Formula: C10H16 N4
• Molecular Weight: 192.264
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40353688
• Wikidata: Q72441093
• ChEMBL ID: CHEMBL1508066
• Mol file: 91717-22-5.mol

Synonyms:2-Amino-4-piperidino-6-methylpyrimidine;91717-22-5;4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine;4-methyl-6-piperidin-1-ylpyrimidin-2-amine;2-Pyrimidinamine, 4-methyl-6-(1-piperidinyl)-;MLS000706633;4-methyl-6-(1-piperidinyl)-2-pyrimidinamine;4-methyl-6-(1-piperidinyl)-2-pyrimidinylamine;SMR000226017;4-methyl-6-piperidin-1-yl-pyrimidin-2-amine;ChemDiv1_000749;Cambridge id 5493483;Oprea1_411252;cid_748221;SCHEMBL6600071;CHEMBL1508066;BDBM90296;HMS589C01;DTXSID40353688;HMS2596E08;HMS3382K10;MFCD01011781;AKOS001605146;DS-0722;FS-2971;SB42966;FT-0602401;(4-methyl-6-piperidino-pyrimidin-2-yl)amine;AB00087022-01;A844049;SR-01000402025;J-507881;SR-01000402025-1

Chemical Property of 2-Amino-4-piperidino-6-methylpyrimidine

Chemical Property:

• Vapor Pressure: 2.54E-07mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 421.8ºC at 760 mmHg
• Flash Point: 208.9ºC
• PSA: 55.04000
• Density: 1.153g/cm3
• LogP: 2.00370
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 192.137496527
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4-piperidino-6-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N)N2CCCCC2

Technology Process of 2-Amino-4-piperidino-6-methylpyrimidine

There total 2 articles about 2-Amino-4-piperidino-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 2-amino-6-methyl-4-chloropyrimidine (5600-21-5) → 4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine (91717-22-5)

Guidance literature:

With water;

DOI:10.1021/jo01143a003

Reference yield:

piperidine (110-89-4) + 2-amino-6-methyl-4-chloropyrimidine (5600-21-5) + water (7732-18-5) → 4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine (91717-22-5)

Guidance literature:

Rate constant; Abhaengigkeit dieser Reaktion von der Aciditaet der Loesung;

DOI:10.1021/jo01143a003

Reference yield: 95.0%

4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine (91717-22-5) + toluene (108-88-3,15644-74-3,16713-13-6) + malonic acid dimethyl ester (108-59-8) → (S)-dimethyl 2-(((4-methyl-6-(piperidin-1-yl)pyrimidin-2-yl)amino)(p-tolyl)methyl)malonate

Guidance literature:

With quinine thiourea; In neat (no solvent); at 60 ℃; for 36h; enantioselective reaction;

DOI:10.1055/s-0037-1609910

upstream raw materials:

piperidine

2-amino-6-methyl-4-chloropyrimidine

water