4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol

Base Information

• Chemical Name: 4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol
• CAS No.: 1194726-47-0
• Molecular Formula: C₁₄H₁₀F₄O₂
• Molecular Weight: 286.226
• Mol file: 1194726-47-0.mol

Synonyms:4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol

Chemical Property of 4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol

Chemical Property:

• Boiling Point: 333.4±42.0 °C(Predicted)
• Density: 1.359±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol

There total 1 articles about 4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-difluoro-4-bromophenol (144292-32-0) + (4-ethoxy 2,3-difluorophenyl)boronic acid (212386-71-5) → 4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol (1194726-47-0)

Guidance literature:

With sodium carbonate; palladium on activated charcoal; In isopropyl alcohol; for 10h; Reflux; Inert atmosphere;

Reference yield:

4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol (1194726-47-0) + 4'-vinylbicyclohexyl-4-ylmethyl-toluene-4-sulfonic acid → 4'-ethoxy-2,3,2',3'-tetrafluoro-4-(4'-vinylbicyclohexyl-4-ylmethoxy)-biphenyl

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 60 ℃; for 14h; Inert atmosphere;

Reference yield:

4-(4-ethoxy-2,3-difluorophenyl)-2,3-difluorophenol (1194726-47-0) + 1-iodidemethyl-trans-4-vinylcyclohexane → 4'-ethoxy-2,3,2',3'-tetrafluoro-4-(trans-4-vinylcyclohexylmethoxy)-biphenyl

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2,3-difluoro-4-bromophenol

(4-ethoxy 2,3-difluorophenyl)boronic acid

Refernces