N-benzyltyrosine tert-butyl ester

Base Information

• Chemical Name: N-benzyltyrosine tert-butyl ester
• CAS No.: 179188-06-8
• Molecular Formula: C₂₀H₂₅NO₃
• Molecular Weight: 327.423
• Mol file: 179188-06-8.mol

Synonyms:N-benzyltyrosine tert-butyl ester

Chemical Property of N-benzyltyrosine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyltyrosine tert-butyl ester

There total 4 articles about N-benzyltyrosine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Tyr(tBu) (16874-12-7,87553-74-0) + benzaldehyde (100-52-7) → N-benzyltyrosine tert-butyl ester (179188-06-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In acetonitrile; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm501827k

Reference yield: 57.0%

Tyr(tBu) (16874-12-7,87553-74-0) + benzyl chloride (100-44-7) → N-benzyltyrosine tert-butyl ester (179188-06-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 45h;

DOI:10.1021/jm960747t

Reference yield:

Tyr(tBu) (16874-12-7,87553-74-0) → N-benzyltyrosine tert-butyl ester (179188-06-8)

Guidance literature:

With sodium cyanoborohydride; benzaldehyde; In methanol;

upstream raw materials:

Tyr(tBu)

benzyl chloride

benzaldehyde

Downstream raw materials:

N-benzyl-2-(4-hydroxybenzyl)-3-azaglutaric acid-di-tert-butyl ester

L-N-(benzyl)-tyrosine

Refernces

• 1、 -. "Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents". . . Retrieved 2008/06/13.
• 2、 Choi, Heekyung,Murray, Thomas F.,DeLander, Gary E.,Schmidt, William K.,Aldrich, Jane V.. "Synthesis and opioid activity of [D-Pro10]Dynorphin A-(1-11) analogues with N-terminal alkyl substitution". . p. 2733 - 2739. Retrieved 2007/10/03.