p-Fluorobenzylamine hydrochloride

Base Information

• Chemical Name: p-Fluorobenzylamine hydrochloride
• CAS No.: 659-41-6
• Molecular Formula: C7H9ClFN
• Molecular Weight: 161.607
• Hs Code.: 2921499090
• European Community (EC) Number: 211-534-0
• DSSTox Substance ID: DTXSID80216107
• Mol file: 659-41-6.mol

Synonyms:659-41-6;4-Fluorobenzylamine hydrochloride;(4-fluorophenyl)methanamine hydrochloride;p-Fluorobenzylamine hydrochloride;4-FLUORO BENZYLAMINE HYDROCHLORIDE;(4-fluorophenyl)methanamine;hydrochloride;p-Fluorobenzylamine HCl;MFCD00012861;(4-Fluorophenyl)methanamine HCl;EINECS 211-534-0;4-FLUOROBENZYLAMINEHYDROCHLORIDE;4-fluorobenzenemethanamine hydrochloride;(4-Fluorophenyl)methanaminehydrochloride;C7H8FN.ClH;4-Fluoro Benzylamine HCl;C7-H8-F-N.Cl-H;SCHEMBL3830237;4-Fluoro-benzylammonium chloride;DTXSID80216107;4-fluoro-benzylamine hydrochloride;TXMNQIDABVFSRY-UHFFFAOYSA-N;4-fluoro-benzylamine hydrogen chloride;AKOS016015003;SB76693;CS-0196433;F1255;FT-0653191;N12249;EN300-7394894;A835286

Chemical Property of p-Fluorobenzylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.738mmHg at 25°C
• Melting Point: 265-268 °C(Solv: ethanol (64-17-5))
• Boiling Point: 184.3 °C at 760 mmHg
• Flash Point: 73.3 °C
• PSA: 26.02000
• LogP: 2.78670
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 161.0407551
• Heavy Atom Count: 10
• Complexity: 77

Purity/Quality:

98%Min ^*data from raw suppliers

4-Fluorobenzylamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CN)F.Cl

Technology Process of p-Fluorobenzylamine hydrochloride

There total 14 articles about p-Fluorobenzylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-fluorobenzonitrile (1194-02-1,143234-87-1) → 4-fluorobenzenemethanamine hydrochloride (659-41-6)

Guidance literature:

With hydrogenchloride; hydrogen; In 1,4-dioxane; methanol; at 60 ℃; for 18h; under 375.038 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield: 96.0%

4,4,5,5-tetramethyl-N-(4-fluorobenzyl)-N-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaborolan-2-amine → 4-fluorobenzenemethanamine hydrochloride (659-41-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.1c00106

Reference yield: 93.0%

4-fluorobenzyl azide (159979-96-1) → 4-fluorobenzenemethanamine hydrochloride (659-41-6)

Guidance literature:

With thiamine diphosphate; In methanol; at 80 ℃; for 1h;

DOI:10.1081/SCC-120030322

upstream raw materials:

1-chloromethyl-4-fluorobenzene

4-fluorobenzyl azide

para-fluorobenzylamine

4-fluorobenzonitrile

Downstream raw materials:

N-<(4-fluorophenyl)methyl>-3-nitro-2-pyridinamine

C₁₅H₂₀FN₅*ClH

4,6-diamino-1-(4'-fluorobenzyl)-1,2-dihydro-2,2-dimethyl-1,3,5-triazine hydrochloride

N₁-(4-fluoro)benzyl biguanide hydrochloride

Refernces

• 1、 Antil, Neha,Kumar, Ajay,Akhtar, Naved,Newar, Rajashree,Begum, Wahida,Dwivedi, Ashutosh,Manna, Kuntal. "Aluminum Metal-Organic Framework-Ligated Single-Site Nickel(II)-Hydride for Heterogeneous Chemoselective Catalysis". . p. 3943 - 3957. Retrieved 2021/04/12.
• 2、 Pandey, Vipin K.,Tiwari, Chandra Shekhar,Rit, Arnab. "Silver-Catalyzed Hydroboration of C-X (X = C, O, N) Multiple Bonds". . p. 1681 - 1686. Retrieved 2021/03/03.