Technology Process of N1-phenyl-4-piperidin-1-ylmethyl-benzene-1,2-diamine
There total 4 articles about N1-phenyl-4-piperidin-1-ylmethyl-benzene-1,2-diamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane
2: N-ethyl-N,N-diisopropylamine / 150 °C
3: tin(II) chloride dihdyrate / ethanol; ethyl acetate / Reflux
With
tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine;
In
ethanol; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2015.10.060
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; dichloromethane
2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane
3: N-ethyl-N,N-diisopropylamine / 150 °C
4: tin(II) chloride dihdyrate / ethanol; ethyl acetate / Reflux
With
sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium bromide;
In
ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2015.10.060
- Guidance literature:
-
Multi-step reaction with 5 steps
1: borane-THF / tetrahydrofuran
2: sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; dichloromethane
3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane
4: N-ethyl-N,N-diisopropylamine / 150 °C
5: tin(II) chloride dihdyrate / ethanol; ethyl acetate / Reflux
With
sodium hypochlorite; borane-THF; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tin(II) chloride dihdyrate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; potassium bromide;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2015.10.060