3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone

Base Information

• Chemical Name: 3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone
• CAS No.: 1293988-24-5
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.445
• Mol file: 1293988-24-5.mol

Synonyms:3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone

Chemical Property of 3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone

There total 6 articles about 3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

3-(3-bromopropoxy)-6-hydroxyxanthone + cyclohexylamine (108-91-8,157973-60-9) → 3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone (1293988-24-5)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.1016/j.ejmech.2011.01.043

Reference yield:

2,4-dimethoxybenzoyl chloride (39828-35-8) → 3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone (1293988-24-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / diethyl ether / 8 h / 20 °C

1.2: Cooling with ice

2.1: pyridine; tetramethyl ammoniumhydroxide / water / 36 h / Reflux

3.1: hydrogen iodide; phenol / water / 8 h / 160 °C

4.1: sodium hydroxide / water; butan-1-ol / 5 h / Reflux

5.1: ethanol / 6 h / Reflux

With pyridine; aluminum (III) chloride; tetramethyl ammoniumhydroxide; hydrogen iodide; sodium hydroxide; phenol; In diethyl ether; ethanol; water; butan-1-ol;

DOI:10.1016/j.ejmech.2011.01.043

Reference yield:

3,6-dimethoxy-9H-xanthen-9-one (15007-07-5) → 3-[3-(cyclohexylamino)-propoxy]-6-hydroxyxanthone (1293988-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen iodide; phenol / water / 8 h / 160 °C

2: sodium hydroxide / water; butan-1-ol / 5 h / Reflux

3: ethanol / 6 h / Reflux

With hydrogen iodide; sodium hydroxide; phenol; In ethanol; water; butan-1-ol;

DOI:10.1016/j.ejmech.2011.01.043

upstream raw materials:

cyclohexylamine

3,6-dihydroxy-xanthen-9-one

2,4 dimethoxybenzoic acid

2,4-dimethoxybenzoyl chloride

Refernces