DL-THREO-4-FLUOROGLUTAMIC ACID

Base Information

• Chemical Name: DL-THREO-4-FLUOROGLUTAMIC ACID
• CAS No.: 91383-47-0
• Molecular Formula: C₅H₈FNO₄
• Molecular Weight: 165.121
• Hs Code.: 2922498590
• Mol file: 91383-47-0.mol

Synonyms:DL-Glutamicacid, 4-fluoro-, threo-; DL-threo-4-Fluoroglutamic acid; threo-g-Fluoroglutamic acid

Chemical Property of DL-THREO-4-FLUOROGLUTAMIC ACID

Chemical Property:

• Vapor Pressure: 1.37E-05mmHg at 25°C
• Melting Point: 194-195°C
• Refractive Index: 1.491
• Boiling Point: 342.4°Cat760mmHg
• Flash Point: 160.9°C
• PSA: 100.62000
• Density: 1.498g/cm³
• LogP: -0.08860

Purity/Quality:

98%min ^*data from raw suppliers

DL-threo-4-Fluoroglutamic acid 99% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-THREO-4-FLUOROGLUTAMIC ACID

There total 54 articles about DL-THREO-4-FLUOROGLUTAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

D,L-erythro,threo-4-fluoroglutamic acid (2708-77-2,149117-03-3,91383-48-1,91383-47-0) → (+/-)-2-Fluoro-4-aminobutanoic acid (5130-17-6,34069-57-3) + (-)-D-erythro-4-fluoroglutamic acid (132746-47-5,149117-03-3,91383-48-1,91383-47-0) + d-threo-(2R,4R)-4-Fluoroglutamic acid (149117-03-3,91383-48-1,91383-47-0)

Guidance literature:

With sodium hydroxide; glutamic decarboxylase ex Escherichia coli; pyridoxal 5'-phosphate; In pyridine; water; at 30 ℃; for 48h;

DOI:10.1016/S0022-1139(99)00188-8

Reference yield: 100.0%

D,L-erythro,threo-4-fluoroglutamic acid (2708-77-2,149117-03-3,91383-48-1,91383-47-0) → (+/-)-2-Fluoro-4-aminobutanoic acid (5130-17-6,34069-57-3) + (-)-D-erythro-4-fluoroglutamic acid (132746-47-5,149117-03-3,91383-48-1,91383-47-0) + d-threo-(2R,4R)-4-Fluoroglutamic acid (149117-03-3,91383-48-1,91383-47-0)

Guidance literature:

With sodium hydroxide; glutamic decarboxylase ex Escherichia coli; pyridoxal 5'-phosphate; In pyridine; water; at 30 ℃; for 48h;

DOI:10.1016/S0022-1139(99)00188-8

Reference yield: 96.0%

dimethyl thero-4-fluoroglutamate hydrochloride (148267-92-9) → D,L-erythro,threo-4-fluoroglutamic acid (2708-77-2,149117-03-3,91383-48-1,91383-47-0)

Guidance literature:

With hydrogenchloride; at 70 ℃; for 3h;

DOI:10.1016/S0022-1139(00)80033-0

upstream raw materials:

ethyl 2-acetamidoacrylate

fluoromalonic acid diethyl ester

2-Acetamino-2,4-dicarboxy-4-fluor-glutarsaeuretetramethylester

1-Acetamino-3-fluor-propan-tetracarbensaeure-(1,1,3,3)-tetraethylester

Downstream raw materials:

3-Fluor-pyrrolidon-2-carbonsaeure-5

methyl trans-3-fluoro-2-pyrrolidone-5-carboxylate

methyl cis-3-fluoro-2-pyrrolidone-5-carboxylate

Refernces

• 1、 -. "[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION". Paragraph 0890. . Retrieved 2016/12/01.
• 2、 Konas,Coward. "Electrophilic fluorination of pyroglutamic acid derivatives: Application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids". . p. 8831 - 8842. Retrieved 2007/10/03.