5-Chloro-2-Methyl-3-nitro-benzoic acid

Base Information

• Chemical Name: 5-Chloro-2-Methyl-3-nitro-benzoic acid
• CAS No.: 154257-81-5
• Molecular Formula: C₈H₆ClNO₄
• Molecular Weight: 215.593
• Hs Code.: 2916399090
• Mol file: 154257-81-5.mol

Synonyms:5-chloro-2-methyl-3-nitrobenzoic acid

Chemical Property of 5-Chloro-2-Methyl-3-nitro-benzoic acid

Chemical Property:

• Boiling Point: 352.1±42.0 °C(Predicted)
• PKA: 2.66±0.20(Predicted)
• Density: 1.517±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-methyl-3-nitrobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-2-methyl-3-nitrobenzoic Acid is used in preparation of the benzene piperidine derivatives and their applications.

Technology Process of 5-Chloro-2-Methyl-3-nitro-benzoic acid

There total 2 articles about 5-Chloro-2-Methyl-3-nitro-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-chloro-2-methylbenzoic acid (7499-06-1) → 5-chloro-2-methyl-3-nitrobenzoic acid (154257-81-5)

Guidance literature:

5-chloro-2-methylbenzoic acid; With sulfuric acid; at -10 ℃; for 0.166667h;

With nitric acid; at -10 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

2-methyl-3-nitrobenzic acid (1975-50-4) → 5-chloro-2-methyl-3-nitrobenzoic acid (154257-81-5)

Guidance literature:

With sulfuric acid; at 100 ℃;

Reference yield: 100.0%

methanol (67-56-1) + 5-chloro-2-methyl-3-nitrobenzoic acid (154257-81-5) → (5-chloro-2-methyl-3-nitrophenyl) methanol (1613329-98-8)

Guidance literature:

5-chloro-2-methyl-3-nitrobenzoic acid; With borane-THF; In tetrahydrofuran; at 0 ℃; for 3h; Reflux;

methanol; In tetrahydrofuran; at 20 ℃; for 2h; Reflux;

upstream raw materials:

5-chloro-2-methylbenzoic acid

2-methyl-3-nitrobenzic acid

Downstream raw materials:

methyl 5-chloro-2-methyl-3-nitrobenzoate

methyl 2-(bromomethyl)-5-chloro-3-nitrobenzoate

(E)-4-(benzylideneamino)-6-chloroisobenzofuran-1(3H)-one

ethyl 7-chloro-3-(1-methyl-1H-imidazol-2-yl)-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinoline-5-carboxylate

Refernces

• 1、 -. "The bridge ring piperazine derivative or its salt and its preparation and use (by machine translation)". Paragraph 0075; 0078; 0079. . Retrieved 2019/01/23.
• 2、 -. "Novel compounds". Paragraph 0082. . Retrieved 2017/09/27.