N,N-DIETHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Base Information

• Chemical Name: N,N-DIETHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE
• CAS No.: 95389-83-6
• Molecular Formula: C₁₀H₂₀N₂O*ClH
• Molecular Weight: 220.743
• Hs Code.: 2933399090
• Mol file: 95389-83-6.mol

Synonyms:4-Piperidinecarboxamide,N,N-diethyl-, monohydrochloride (9CI);Isonipecotamide, N,N-diethyl-,hydrochloride (6CI,7CI);4-(Diethylaminocarbonyl)piperidine hydrochloride;

Chemical Property of N,N-DIETHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 269.1±29.0°C at 760 mmHg (Cal.) ref.
• Flash Point: 116.5±24.3°C (Cal.) ref.
• PSA: 32.34000
• Density: 1.0±0.1g/cm3 (Cal.) ref.
• LogP: 1.98520

Purity/Quality:

98%min ^*data from raw suppliers

N,N-Diethyl-4-piperidinecarboxamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DIETHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

There total 1 articles about N,N-DIETHYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-diethylisonicotinamide (530-40-5) → N,N-diethyl-4-piperidinecarboxamide hydrochloride (95389-83-6)

Guidance literature:

With 1,1,2-trichloroethane; palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 15h; under 2585.81 Torr;

DOI:10.1016/j.tet.2009.08.011

Reference yield: 76.6%

N,N-diethyl-4-piperidinecarboxamide hydrochloride (95389-83-6) → 4-(N,N-diethylaminomethyl)piperidine (116905-90-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1248/cpb.42.74

Reference yield:

N,N-diethyl-4-piperidinecarboxamide hydrochloride (95389-83-6) → 1-(2-phenoxy-ethyl)-piperidine-4-carboxylic acid diethylamide

Guidance literature:

With methanol; sodium carbonate;

DOI:10.1021/ja01576a050

upstream raw materials:

N,N-diethylisonicotinamide

Downstream raw materials:

4-(N,N-diethylaminomethyl)piperidine

2-Chloro-1-(4-diethylaminomethyl-piperidin-1-yl)-2,2-diphenyl-ethanone

Refernces