ACETIC ACID 4-(3-OXO-PROPYL)-PHENYL ESTER

Base Information

• Chemical Name: ACETIC ACID 4-(3-OXO-PROPYL)-PHENYL ESTER
• CAS No.: 91143-05-4
• Molecular Formula: C11H12 O3
• Molecular Weight: 192.214
• Mol file: 91143-05-4.mol

Synonyms:Hydrocinnamaldehyde,p-hydroxy-, acetate (7CI); 3-(4-Acetoxyphenyl)propanal;4-(Acetyloxy)benzenepropanal

Chemical Property of ACETIC ACID 4-(3-OXO-PROPYL)-PHENYL ESTER

Chemical Property:

• Vapor Pressure: 0.00184mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 292.4°C at 760 mmHg
• Flash Point: 126.4°C
• PSA: 43.37000
• Density: 1.106g/cm³
• LogP: 1.74340

Purity/Quality:

97% ^*data from raw suppliers

4-(ACETYLOXY)BENZENEPROPANAL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ACETIC ACID 4-(3-OXO-PROPYL)-PHENYL ESTER

There total 10 articles about ACETIC ACID 4-(3-OXO-PROPYL)-PHENYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(3-hydroxypropyl)phenyl acetate (107866-55-7) → 4-(3-oxopropyl)phenyl acetate (91143-05-4)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.102

Reference yield: 46.0%

p-acetoxystyrene (2628-16-2) + carbon monoxide (201230-82-2) → 4-(3-oxopropyl)phenyl acetate (91143-05-4) + 4-(1-oxopropan-2-yl)phenylacetate

Guidance literature:

With RuH(CO)(PPh₃)3; hydrogen; In benzene; at 20 ℃; for 40h;

DOI:10.1039/c4ob01958j

Reference yield:

p-acetoxystyrene (2628-16-2) + carbon monoxide (201230-82-2) → p-ethylphenyl acetate (3245-23-6,746657-65-8) + 4-(3-oxopropyl)phenyl acetate (91143-05-4) + 4-(1-oxopropan-2-yl)phenylacetate

Guidance literature:

With C₂₄H₂₃Cl₃P₂Pt; hydrogen; tin(ll) chloride; In toluene; at 50 ℃; for 96h; under 30003 Torr; chemoselective reaction; Autoclave; Inert atmosphere;

DOI:10.1016/j.jorganchem.2010.11.045

upstream raw materials:

p-acetoxystyrene

carbon monoxide

4-(3-hydroxypropyl)phenyl acetate

3-(4-hydroxy-phenyl)-propionic acid ethyl ester

Downstream raw materials:

(S)-4-(3-hydroxyhex-5-enyl)phenyl acetate

4-(3-hydroxypropyl)phenyl acetate

(2R,4S,6R)-2-(4-hydroxyphenethyl)-6-(4-hydroxyphenyl)tetrahydro-2H-pyran-4-ol

(1R,3R,5R)-1,7-bis(4-hydroxyphenyl)-1,5-epoxy-3-hydroxyheptane

Refernces

• 1、 Casnati, Alessandra,Lichosyt, Dawid,Lainer, Bruno,Veth, Lukas,Dydio, Pawe?. "Multicatalytic approach to one-pot stereoselective synthesis of secondary benzylic alcohols". . p. 3502 - 3506. Retrieved 2021/05/10.
• 2、 Christensen, Stig Holden,Olsen, Esben P. K.,Rosenbaum, Jascha,Madsen, Robert. "Hydroformylation of olefins and reductive carbonylation of aryl halides with syngas formed ex situ from dehydrogenative decarbonylation of hexane-1,6-diol". . p. 938 - 945. Retrieved 2015/02/19.