MIBRT

Base Information

• Chemical Name: MIBRT
• CAS No.: 219691-82-4
• Molecular Formula: C₁₆H₁₄Br₂O₄
• Molecular Weight: 430.093
• Mol file: 219691-82-4.mol

Synonyms:MIBRT

Chemical Property of MIBRT

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MIBRT

There total 2 articles about MIBRT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ MIBRT (219691-82-4)

Guidance literature:

Reference yield:

methyl 3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoate (280779-37-5) → MIBRT (219691-82-4)

Guidance literature:

methyl 3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoate; With sodium hydride; Merrifield resin; In N,N-dimethyl-formamide; at 50 ℃; for 40h; Polystyrene

With sodium hydroxide; water; In methanol; at 80 ℃; for 24h;

Reference yield: 92.5%

D-Valine methyl ester (4070-48-8,18869-42-6,21685-47-2) + MIBRT (219691-82-4) → D-N-[3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoyl]valine (280777-33-5)

Guidance literature:

D-Valine methyl ester; MIBRT; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 48h; Polystyrene

With sodium hydroxide; water; In methanol; for 48h;

upstream raw materials:

methyl 3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoate

Downstream raw materials:

D-N-[3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoyl]valine

3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzoyl-(5-hydroxy-1-naphthalenesulphonyl)-amide

3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)benzylalcohol

Refernces

• 1、 -. "Thyroid receptor ligands and method". . . Retrieved 2008/06/13.