Roxatidine

Base Information Edit

Chemical Name:Roxatidine
CAS No.:78273-80-0
Molecular Formula:C17H26 N2 O3
Molecular Weight:306.405
Hs Code.:2933399090
UNII:IV9VHT3YUM
DSSTox Substance ID:DTXSID30228937
Nikkaji Number:J94.752K
Wikidata:Q415039
NCI Thesaurus Code:C152265
ChEMBL ID:CHEMBL4802233
Mol file:78273-80-0.mol

Synonyms:roxatidine;roxatidine acetate;roxatidine acetate hydrochloride;Roxiwas;Zarocs

Suppliers and Price of Roxatidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ROXATIDINE 95.00%
5MG
$ 504.65

Total 48 raw suppliers

Chemical Property of Roxatidine Edit

Chemical Property:

Vapor Pressure:8.09E-12mmHg at 25°C
Melting Point:59-60 °C
Boiling Point:524.3 °C at 760 mmHg
PKA:13.34±0.10(Predicted)
Flash Point:270.9 °C
PSA：61.80000
Density:1.137 g/cm³
LogP:1.87870
Storage Temp.:-20°
Solubility.:Soluble in DMSO (up to 25 mg/ml).
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:306.19434270
Heavy Atom Count:22
Complexity:319

Purity/Quality:

99% ^*data from raw suppliers

ROXATIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)CC2=CC(=CC=C2)OCCCNC(=O)CO
Recent ClinicalTrials:Proton Pump Inhibitors and Risk of Community-acquired Pneumonia
Recent NIPH Clinical Trials:study of effect of H2RA for the epigastric symptoms
Description Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4
Uses Anti-ulcerative.

Technology Process of Roxatidine

There total 10 articles about Roxatidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%