5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

Base Information

• Chemical Name: 5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole
• CAS No.: 1338457-70-7
• Molecular Formula: C₂₁H₂₄N₄O₁₁S
• Molecular Weight: 540.508
• Mol file: 1338457-70-7.mol

Synonyms:5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

Chemical Property of 5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole

There total 1 articles about 5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

2,3,4-tri-O-acetyl-1-azido-1-deoxy-β-D-glucopyranuronic acid methyl ester (67776-38-9,163776-36-1) + 1‐ethynyl‐4‐(methylsulfonyl)benzene (340771-31-5) → 5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole (1338457-70-7)

Guidance literature:

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In toluene; at 100 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.08.066

Reference yield:

5-[p-(aminosulfonyl)phenyl]-1-(2',3',4'-tri-O-acetyl-D-glucuronic acid methyl ester)-1H-1,2,3-triazole (1338457-70-7) → C15H18N4O8S

Guidance literature:

With methanol; sodium methylate; at 0 - 20 ℃; for 16.5h; pH=12;

DOI:10.1016/j.bmcl.2011.08.066

upstream raw materials:

2,3,4-tri-O-acetyl-1-azido-1-deoxy-β-D-glucopyranuronic acid methyl ester

1‐ethynyl‐4‐(methylsulfonyl)benzene

Refernces