C₂₃H₂₃BrN₄O₃

Base Information

• Chemical Name: C₂₃H₂₃BrN₄O₃
• CAS No.: 1255936-26-5
• Molecular Formula: C₂₃H₂₃BrN₄O₃
• Molecular Weight: 483.365
• Mol file: 1255936-26-5.mol

Synonyms:C₂₃H₂₃BrN₄O₃

Chemical Property of C₂₃H₂₃BrN₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₃BrN₄O₃

There total 5 articles about C₂₃H₂₃BrN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole (1255936-24-3) + (2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid (50890-96-5) → C23H23BrN4O3 (1255936-26-5)

Guidance literature:

With HATU; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

(R)-phenylglycine (875-74-1) → C23H23BrN4O3 (1255936-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 1.33 h / 0 °C

2: HATU / N,N-dimethyl-formamide / 15 h / 20 °C

With HATU; sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → C23H23BrN4O3 (1255936-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / 96 h / 20 °C

2: ammonium acetate / o-xylene / 2.5 h / 140 °C

3: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

4: HATU / N,N-dimethyl-formamide / 15 h / 20 °C

With ammonium acetate; triethylamine; HATU; trifluoroacetic acid; In dichloromethane; o-xylene; N,N-dimethyl-formamide;

upstream raw materials:

(S)-5-(4-bromophenyl)-2-(pyrrolidin-2-yl)-1H-imidazole

(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

(R)-phenylglycine

1-(tert-butoxycarbonyl)-L-proline

Refernces

• 1、 -. "FUSED TRICYCLIC ARYL COMPOUNDS USEFUL FOR THE TREATMENT OF VIRAL DISEASES". Page/Page column 107. . Retrieved 2010/12/17.