N-METHYL-3-FLUOROBENZYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: N-METHYL-3-FLUOROBENZYLAMINE HYDROCHLORIDE
• CAS No.: 90389-40-5
• Molecular Formula: C8H10 F N . Cl H
• Molecular Weight: 175.633
• Mol file: 90389-40-5.mol

Synonyms:Benzenemethanamine,3-fluoro-N-methyl-, hydrochloride (9CI)

Chemical Property of N-METHYL-3-FLUOROBENZYLAMINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 168.7°Cat760mmHg
• Flash Point: 55.8°C
• PSA: 12.03000
• Density: 1.028g/cm³
• LogP: 2.73800

Purity/Quality:

98% ^*data from raw suppliers

1-(3-Fluorophenyl)-N-methylmethanaminehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYL-3-FLUOROBENZYLAMINE HYDROCHLORIDE

There total 1 articles about N-METHYL-3-FLUOROBENZYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-(Bromomethyl)-3-fluorobenzene (456-41-7) + methylamine (74-89-5) → N-methyl-3-fluorobenzylamine hydrochloride (90389-40-5)

Guidance literature:

1-(Bromomethyl)-3-fluorobenzene; methylamine; In tetrahydrofuran; at 20 ℃; for 6h;

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/acs.jmedchem.1c01784

Reference yield: 74.0%

3-(bromomethyl)-7-methoxy-2H-chromen-2-one (133932-20-4) + N-methyl-3-fluorobenzylamine hydrochloride (90389-40-5) → 3-{[(3-fluorobenzyl)(methyl)amino]methyl}-7-methoxy-2H-chromen-2-one

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.3390/molecules21030362

Reference yield: 60.0%

3-(bromomethyl)-2H-1-benzopyran-2-one (95306-70-0) + N-methyl-3-fluorobenzylamine hydrochloride (90389-40-5) → 3-{[(3-fluorobenzyl)(methyl)amino]methyl}-2H-chromen-2-one hydrochloride

Guidance literature:

3-(bromomethyl)-2H-1-benzopyran-2-one; N-methyl-3-fluorobenzylamine hydrochloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In 1,4-dioxane;

DOI:10.3390/molecules21030362

upstream raw materials:

1-(Bromomethyl)-3-fluorobenzene

methylamine

Refernces