Technology Process of N2-isobutyryl-7-<5-O-(4,4'-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl>guanine
There total 6 articles about N2-isobutyryl-7-<5-O-(4,4'-dimethoxytrityl)-2-deoxy-β-D-erythro-pentofuranosyl>guanine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) chlorotrimethylsilane / 1.) pyridine, 1 h, 2.) pyridine, 2 h
2: 72 percent / pyridine / 2.5 h / Ambient temperature
3: 69 percent / 4-dimethylaminopyridine / acetonitrile / 4 h / Ambient temperature
4: 67 percent / 2,2'-azobis(2-methylpropionitrile, tributyltin hydride / toluene / 3.5 h / 75 °C
5: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature
6: 72 percent / pyridine / 2.5 h / Ambient temperature
With
dmap; chloro-trimethyl-silane; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride;
In
tetrahydrofuran; pyridine; toluene; acetonitrile;
DOI:10.1002/jhet.5570310441
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / pyridine / 2.5 h / Ambient temperature
2: 69 percent / 4-dimethylaminopyridine / acetonitrile / 4 h / Ambient temperature
3: 67 percent / 2,2'-azobis(2-methylpropionitrile, tributyltin hydride / toluene / 3.5 h / 75 °C
4: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature
5: 72 percent / pyridine / 2.5 h / Ambient temperature
With
dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride;
In
tetrahydrofuran; pyridine; toluene; acetonitrile;
DOI:10.1002/jhet.5570310441