Glycine,N-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyl]-N-(carboxymethyl)-, 1-ethyl ester(9CI)

Base Information

• Chemical Name: Glycine,N-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyl]-N-(carboxymethyl)-, 1-ethyl ester(9CI)
• CAS No.: 90359-20-9
• Molecular Formula: C16H28 N2 O8
• Molecular Weight: 376.407
• Mol file: 90359-20-9.mol

Synonyms:EDTA-TRIETHYL ESTER;ETHYLENEDIAMINE TETRAACETIC ACID TRIETHYL ESTER;ETHYLENEDIAMINETETRAACETIC ACID TRIETHYL ESTER HYDROCHLORIDE;ethylenediaminetetraacetic acid*triethyl ester hy;EDTA triethyl ester hydrochloride

Chemical Property of Glycine,N-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyl]-N-(carboxymethyl)-, 1-ethyl ester(9CI)

Chemical Property:

• PSA: 122.68000
• LogP: 0.16630

Purity/Quality:

TRIETHYL ETHYLENEDIAMINE TETRAACETATE 98.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 45-46-20/21/22-36/37/38
• Safety Statements: 53-22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine,N-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyl]-N-(carboxymethyl)-, 1-ethyl ester(9CI)

There total 3 articles about Glycine,N-[2-[bis(2-ethoxy-2-oxoethyl)amino]ethyl]-N-(carboxymethyl)-, 1-ethyl ester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethylenediaminetetraacetic acid tetraethyl ester (3626-00-4) → {[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetic acid (90359-20-9)

Guidance literature:

With sodium hydroxide; hydrogen sulfide; In water;

DOI:10.1016/0040-4020(84)85050-4

Reference yield:

ethylenediaminetetraacetic acid (60-00-4,94108-75-5) → {[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetic acid (90359-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / H₂SO₄ / 6 h / Heating

2: 78 percent / aq. Na₂HPO₄; KH₂PO₄; pig liver esterase / 8 h / 27 °C

With disodium hydrogenphosphate; potassium dihydrogenphosphate; pig liver esterase; sulfuric acid;

DOI:10.1515/znb-2005-0113

Reference yield:

→ {[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetic acid (90359-20-9)

Guidance literature:

upstream raw materials:

ethylenediaminetetraacetic acid tetraethyl ester

ethylenediaminetetraacetic acid

Downstream raw materials:

5-(2-{[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-ethoxycarbonylmethyl-amino}-acetylamino)-2-hydroxy-benzoic acid

5-(2-{[2-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetylamino)-2-hydroxy-benzoic acid

5'-O-(4,4'-dimethoxytrityl)-N⁴-[trans-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine

5'-O-(4,4'-dimethoxytrityl)-N⁴-[6-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)hexyl]-2'-deoxycytidine

Refernces

• 1、 Csuk, René,Raschke, Christian,G?the, Gunnar,Rei?mann, Stefan. "Synthesis of monomeric acridine derived nucleic acid intercalators". . p. 83 - 88. Retrieved 2007/10/03.
• 2、 Tuntiwechapikul,Jeong Tae Lee,Salazar. "Design and synthesis of the G-quadruplex-specific cleaving reagent perylene-EDTA·iron(II) [16]". . p. 5606 - 5607. Retrieved 2007/10/03.