Technology Process of 4-chloro-6-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one
There total 8 articles about 4-chloro-6-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
acetonitrile;
at 90 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: copper(I) bromide; potassium carbonate; sodium hydroxide; copper diacetate / N,N-dimethyl-formamide / 16.17 h / 100 - 110 °C
2: palladium diacetate; caesium carbonate; 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / toluene / 4 h / 110 °C / Reflux; Inert atmosphere
3: triethylamine / dichloromethane / 2 h / Cooling with ice
4: hydrogenchloride; methanol / 1 h / 20 °C
5: triethylamine / acetonitrile / 12 h / 90 °C
With
hydrogenchloride; methanol; 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; copper diacetate; palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; copper(I) bromide; sodium hydroxide;
In
dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: palladium diacetate; caesium carbonate; 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / toluene / 4 h / 110 °C / Reflux; Inert atmosphere
2: triethylamine / dichloromethane / 2 h / Cooling with ice
3: hydrogenchloride; methanol / 1 h / 20 °C
4: triethylamine / acetonitrile / 12 h / 90 °C
With
hydrogenchloride; methanol; 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; palladium diacetate; caesium carbonate; triethylamine;
In
dichloromethane; toluene; acetonitrile;