4-ethoxy-N-ethylaniline

Base Information

• Chemical Name: 4-ethoxy-N-ethylaniline
• CAS No.: 65570-13-0
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.235
• Mol file: 65570-13-0.mol

Synonyms:4-ethoxy-N-ethylaniline

Chemical Property of 4-ethoxy-N-ethylaniline

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

4-ethoxy-N-ethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-ethoxy-N-ethylaniline

There total 5 articles about 4-ethoxy-N-ethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-Ethoxyaniline (156-43-4) + acetonitrile (75-05-8,26809-02-9) → 4-ethoxy-N-ethylaniline (65570-13-0) + 4-ethoxy-N,N-diethylaniline (133317-05-2)

Guidance literature:

With palladium 10% on activated carbon; ammonium acetate; hydrogen; In methanol; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1039/c1ob06303k

Reference yield: 79.0%

ethanol (64-17-5) + 4-Ethoxyaniline (156-43-4) → 4-ethoxy-N-ethylaniline (65570-13-0)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; L-phenylalanineanilide; potassium tert-butylate; at 65 ℃; for 24h; Inert atmosphere; Molecular sieve;

DOI:10.1021/jo501273t

Reference yield:

4-ethoxy-N,N-diethylaniline (133317-05-2) → 4-ethoxy-N-ethylaniline (65570-13-0) + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

With rhodium(III) 5,10,15,20-tetra(p-sulfonatophenyl)porphyrin; oxygen; In methanol; water; at 90 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/c2cc37263k

upstream raw materials:

ethyl bromide

4-Ethoxyaniline

acetonitrile

4-ethoxy-N,N-diethylaniline

Downstream raw materials:

N,N'-diethyl-N,N'-bis-(4-hydroxy-phenyl)-hydrazine

acetic acid-(N-ethyl-p-phenetidide)

N-ethyl-N-nitroso-p-phenetidine

N,N'-bis-(4-ethoxy-phenyl)-N,N'-diethyl-hydrazine

Refernces

• 1、 Enyong, Arrey B.,Moasser, Bahram. "Ruthenium-catalyzed N-alkylation of amines with alcohols under mild conditions using the borrowing hydrogen methodology". . p. 7553 - 7563. Retrieved 2014/09/17.
• 2、 Ikawa, Takashi,Fujita, Yuki,Mizusaki, Tomoteru,Betsuin, Sae,Takamatsu, Haruki,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao. "Selective N-alkylation of amines using nitriles under hydrogenation conditions: Facile synthesis of secondary and tertiary amines". supporting information; experimental part. p. 293 - 304. Retrieved 2012/02/01.