5-Bromopyridine-3,4-dicarboxylic acid

Base Information

• Chemical Name: 5-Bromopyridine-3,4-dicarboxylic acid
• CAS No.: 90325-36-3
• Molecular Formula: C₇H₄BrNO₄
• Molecular Weight: 246.017
• Hs Code.: 2933399090
• Mol file: 90325-36-3.mol

Synonyms:5-Bromo-3,4-pyridinedicarboxylicacid;

Chemical Property of 5-Bromopyridine-3,4-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.663
• Boiling Point: 518.632 °C at 760 mmHg
• Flash Point: 267.459 °C
• PSA: 87.49000
• Density: 1.985 g/cm³
• LogP: 1.24050
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-BROMOPYRIDINE-3,4-DICARBOXYLICACID 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromopyridine-3,4-dicarboxylic acid

There total 2 articles about 5-Bromopyridine-3,4-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-bromo-3-pyridinecarboxylic acid (20826-04-4) + carbon dioxide (124-38-9,18923-20-1) → 5-bromopyridine-3,4-dicarboxylic acid (90325-36-3)

Guidance literature:

5-bromo-3-pyridinecarboxylic acid; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.5h;

carbon dioxide; In tetrahydrofuran; hexane;

With hydrogenchloride; In water; pH=3;

DOI:10.1016/S0040-4020(02)00673-7

Reference yield:

4-bromoisoquinoline (1532-97-4) → 5-bromopyridine-3,4-dicarboxylic acid (90325-36-3)

Guidance literature:

With potassium permanganate; at 50 - 60 ℃;

Reference yield:

5-bromopyridine-3,4-dicarboxylic acid (90325-36-3) → 3-Hydroxy-pyridin-4,5-dicarbonsaeure ('Nor-Ichitasaeure') (17285-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CuSO₄; aqueous NH₃ / 200 °C

2: nitrosylsulfuric acid; H₂O / 80 °C / Ueber das Diazoniumsulfat

With ammonium hydroxide; nitrosylsulfuric acid; water; copper(II) sulfate;

DOI:10.1021/ja01216a522

upstream raw materials:

4-bromoisoquinoline

5-bromo-3-pyridinecarboxylic acid

carbon dioxide

Downstream raw materials:

3-Hydroxy-pyridin-4,5-dicarbonsaeure ('Nor-Ichitasaeure')

Refernces

• 1、 Lazaar, Jalal,Rebstock, Anne-Sophie,Mongin, Florence,Godard, Alain,Trécourt, Fran?ois,Marsais, Francis,Quéguiner, Guy. "Directed lithiation of unprotected pyridinecarboxylic acids: Syntheses of halo derivatives". . p. 6723 - 6728. Retrieved 2007/10/03.