((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol

Base Information

• Chemical Name: ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol
• CAS No.: 120591-55-1
• Molecular Formula: C₃₀H₃₄O₂
• Molecular Weight: 426.599
• Mol file: 120591-55-1.mol

Synonyms:((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol

Chemical Property of ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol

There total 7 articles about ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

methyl 13-methoxy-8,11,13-podocarpatrien-18-oate (30801-09-3) + phenylmagnesium bromide → ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol (120591-55-1)

Guidance literature:

In diethyl ether; at 90 - 100 ℃; for 5.5h;

DOI:10.1246/bcsj.61.723

Reference yield:

methyl 13-acetyl-7-oxo-8,11,13-podocarpatrien-18-oate (5335-63-7) → ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol (120591-55-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 31.6 percent / aq. hydrochloride acid / diethyl ether

2: 97.2 percent / potassium carbonate / butan-2-one / 8 h / Heating

3: 87.1 percent / 10percent Pd-C, perchloric acid, H₂ / acetic acid / 9 h / Ambient temperature

4: 81.2 percent / diethyl ether / 5.5 h / 90 - 100 °C

With hydrogenchloride; palladium on activated charcoal; perchloric acid; hydrogen; potassium carbonate; In diethyl ether; acetic acid; butanone;

DOI:10.1246/bcsj.61.723

Reference yield:

methyl 13-hydroxy-7-oxo-8,11,13-podocarpatrien-18-oate (26906-78-5) → ((1R,4aS,10aR)-7-Methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-diphenyl-methanol (120591-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 97.2 percent / potassium carbonate / butan-2-one / 8 h / Heating

2: 87.1 percent / 10percent Pd-C, perchloric acid, H₂ / acetic acid / 9 h / Ambient temperature

3: 81.2 percent / diethyl ether / 5.5 h / 90 - 100 °C

With palladium on activated charcoal; perchloric acid; hydrogen; potassium carbonate; In diethyl ether; acetic acid; butanone;

DOI:10.1246/bcsj.61.723

upstream raw materials:

methyl 13-methoxy-8,11,13-podocarpatrien-18-oate

methyl 13-acetyl-7-oxo-8,11,13-podocarpatrien-18-oate

methyl 13-hydroxy-7-oxo-8,11,13-podocarpatrien-18-oate

13-acetyl-7-oxo-8,11,13-podocarpatrien-18-oic acid

Refernces