1-(1-Phenylcyclohexyl)morpholine hydrochloride

Base Information

• Chemical Name: 1-(1-Phenylcyclohexyl)morpholine hydrochloride
• CAS No.: 1934-49-2
• Molecular Formula: C₁₆H₂₃NO*ClH
• Molecular Weight: 281.826
• European Community (EC) Number: 695-023-1
• DSSTox Substance ID: DTXSID90941014
• Mol file: 1934-49-2.mol

Synonyms:1-(1-phenylcyclohexyl)morpholine;1-(1-phenylcyclohexyl)morpholine hydrochloride;1-PCHM

Chemical Property of 1-(1-Phenylcyclohexyl)morpholine hydrochloride

Chemical Property:

• Vapor Pressure: 5.43E-05mmHg at 25°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 281.1546421
• Heavy Atom Count: 19
• Complexity: 248

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)(C2=CC=CC=C2)N3CCOCC3.Cl

Technology Process of 1-(1-Phenylcyclohexyl)morpholine hydrochloride

There total 2 articles about 1-(1-Phenylcyclohexyl)morpholine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromobenzene (108-86-1,52753-63-6) + 1-(morpholin-4-yl)cyclohexanecarbonitrile (42419-59-0) → 1-[1-phenylcyclohexyl]morpholine hydrochloride (1934-49-2)

Guidance literature:

bromobenzene; With iodine; magnesium; In diethyl ether;

1-(morpholin-4-yl)cyclohexanecarbonitrile; In tetrahydrofuran; diethyl ether;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1016/j.pbb.2010.12.019

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-[1-phenylcyclohexyl]morpholine hydrochloride (1934-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogensulfite

2: iodine; magnesium / diethyl ether

With iodine; sodium hydrogensulfite; magnesium; In diethyl ether;

DOI:10.1016/j.pbb.2010.12.019

upstream raw materials:

cyclohexanone

bromobenzene

1-(morpholin-4-yl)cyclohexanecarbonitrile

Refernces