1-Piperazinecarboxylicacid,3-methyl-,ethylester(7CI,9CI)

Base Information

• Chemical Name: 1-Piperazinecarboxylicacid,3-methyl-,ethylester(7CI,9CI)
• CAS No.: 90152-49-1
• Molecular Formula: C₈H₁₆N₂O₂
• Molecular Weight: 172.227
• Mol file: 90152-49-1.mol

Synonyms:1-(Ethoxycarbonyl)-3-methylpiperazine;3-Methylpiperazine-1-carboxylic acid ethyl ester; Ethyl 3-methyl-1-piperazinecarboxylate

Chemical Property of 1-Piperazinecarboxylicacid,3-methyl-,ethylester(7CI,9CI)

Chemical Property:

• PSA: 41.57000
• LogP: 0.70330

Purity/Quality:

3-methyl-1-Piperazinecarboxylicacidethylester 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperazinecarboxylicacid,3-methyl-,ethylester(7CI,9CI)

There total 6 articles about 1-Piperazinecarboxylicacid,3-methyl-,ethylester(7CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-benzyl-3-methyl-piperazine-1-carboxylic acid ethyl ester (92699-31-5) → 3-methylpiperazine-1-carboxylic acid ethyl ester (90152-49-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 12h; under 1838.8 Torr;

Reference yield:

(RS)-2-methylpiperazine (109-07-9) + chloroformic acid ethyl ester (541-41-3) → 3-methylpiperazine-1-carboxylic acid ethyl ester (90152-49-1)

Guidance literature:

in wss. Loesung vom pH 3-3.5;

DOI:10.1021/jo01159a018 DOI:10.1021/ja01123a008

Reference yield:

3-methylpiperazin-2-one (23936-11-0) → 3-methylpiperazine-1-carboxylic acid ethyl ester (90152-49-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / methanol / 24 h / Heating

2: 70 percent / lithium aluminium hydride / tetrahydrofuran / 72 h / Heating

3: 67 percent / triethylamine / benzene / Heating

4: 70 percent / hydrogen / 10percent Pd-C / acetic acid / 12 h / 1838.8 Torr

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; benzene;

upstream raw materials:

(RS)-2-methylpiperazine

chloroformic acid ethyl ester

4-benzyl-3-methyl-piperazine-1-carboxylic acid ethyl ester

3-methylpiperazin-2-one

Downstream raw materials:

1,2-dimethylpiperazine

3,4-dimethyl-piperazine-1-carboxylic acid ethyl ester

Refernces

• 1、 -. "2-PHENYL-6-AMINOCARBONYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS". Page/Page column 24. . Retrieved 2010/01/29.
• 2、 -. "SUBSTITUTED 2-PHENYL-PYRIDINE DERIVATIVES". Page/Page column 76-77. . Retrieved 2009/11/29.