1-CHLORO-4-IODO-2,5-DIMETHOXYBENZENE

Base Information

• Chemical Name: 1-CHLORO-4-IODO-2,5-DIMETHOXYBENZENE
• CAS No.: 90064-46-3
• Molecular Formula: C8H8 Cl I O2
• Molecular Weight: 298.508
• Hs Code.: 2908990000
• Mol file: 90064-46-3.mol

Synonyms:2,5-Dimethoxy-4-iodochlorobenzene

Chemical Property of 1-CHLORO-4-IODO-2,5-DIMETHOXYBENZENE

Chemical Property:

• Vapor Pressure: 0.000455mmHg at 25°C
• Melting Point: 115-116
• Refractive Index: 1.584
• Boiling Point: 324.8°Cat760mmHg
• Flash Point: 150.2°C
• PSA: 18.46000
• Density: 1.74g/cm³
• LogP: 2.96180
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Chloro-2,5-dimethoxy-4-iodobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CHLORO-4-IODO-2,5-DIMETHOXYBENZENE

There total 7 articles about 1-CHLORO-4-IODO-2,5-DIMETHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-chloro-1,4-dimethoxybenzene (2100-42-7) → 1-chloro-4-iodo-2,5-dimethoxybenzene (90064-46-3)

Guidance literature:

With iodine; mercury(II) oxide; ultrasound, 10 min, 90 deg C, 30 min;

Reference yield: 23.0%

1,4-dimethoxybezene (150-78-7) → 1-chloro-4-iodo-2,5-dimethoxybenzene (90064-46-3)

Guidance literature:

With Iodine monochloride; In dichloromethane; 1.) RT, 1 h, 2.) reflux, 20 min;

DOI:10.1021/jm00374a023

Reference yield:

1,4-dimethoxybezene (150-78-7) → 1,4-diiodo-2,5-dimethoxybenzene (51560-21-5) + 1-chloro-4-iodo-2,5-dimethoxybenzene (90064-46-3)

Guidance literature:

With Iodine monochloride; In acetonitrile; at 70 ℃; for 4h;

DOI:10.1021/op025566h

upstream raw materials:

2-chloro-1,4-dimethoxybenzene

1-iodo-2,4-dimethoxybenzene

4-chloro-2,5-dimethoxy-aniline

1,4-dimethoxybezene

Downstream raw materials:

4-chloro-2,5-dimethoxybenzaldehyde

2,5-dimethoxyterephthalaldehyde

2-chloro-5-iodo-1,4-benzoquinone

C₉H₈ClF₃O₂

Refernces

• 1、 Huenig, Siegfried,Bau, Robert,Kemmer, Martina,Meixner, Hubert,Metzenthin, Tobias,et al.. "Multistep Reversible Redox Systems, LXIII. 2,5-Disubstituted N,N'-Dicyanoquinone Diimines (DCNQIs) - Syntheses, and Redox Properties". . p. 335 - 348. Retrieved 2007/10/03.