6-HYDROXY-2-METHOXY-7-DEAZAPURINE

Base Information

• Chemical Name: 6-HYDROXY-2-METHOXY-7-DEAZAPURINE
• CAS No.: 90057-07-1
• Molecular Formula: C7H7 N3 O2
• Molecular Weight: 165.15
• Hs Code.: 2933990090
• Mol file: 90057-07-1.mol

Synonyms:4H-Pyrrolo[2,3-d]pyrimidin-4-one,1,7-dihydro-2-methoxy- (9CI); NSC 622774

Chemical Property of 6-HYDROXY-2-METHOXY-7-DEAZAPURINE

Chemical Property:

• Vapor Pressure: 1.52E-05mmHg at 25°C
• Melting Point: >250掳C (dec.)
• Refractive Index: 1.705
• Boiling Point: 365.9°C at 760 mmHg
• Flash Point: 175.1°C
• PSA: 71.03000
• Density: 1.56g/cm³
• LogP: 0.67210
• Storage Temp.: -20°C Freezer

Purity/Quality:

99%, ^*data from raw suppliers

6-Hydroxy-2-methoxy-7-deazapurine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Hydroxy-2-methoxy-7-deazapurine (cas# 90057-07-1) is a compound useful in organic synthesis.

Technology Process of 6-HYDROXY-2-METHOXY-7-DEAZAPURINE

There total 3 articles about 6-HYDROXY-2-METHOXY-7-DEAZAPURINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

ethyl 2-cyano-4,4-diethoxybutyrate (52133-67-2) + O-methylisourea hemisulfate (52328-05-9,24285-39-0) → 3,4-dihydro-2-methoxy-4-oxo-7H-pyrrolo<2,3-d>pyrimidine (90057-07-1)

Guidance literature:

With sodium methylate; In methanol; for 4h; Heating;

DOI:10.1002/jlac.198419840210

Reference yield: 7.0%

2-chloroethanal (107-20-0) + 6-amino-2-methoxy-3H-4-pyrimidone (52386-29-5) → 3,4-dihydro-2-methoxy-4-oxo-7H-pyrrolo<2,3-d>pyrimidine (90057-07-1) + 4-amino-2-methoxyfuro<2,3-d>pyrimidine (130056-76-7) + 5-methoxyoxazolo<3,2-c>pyrrolo<3,2-e>pyrimidine (130056-77-8)

Guidance literature:

With sodium acetate; In water; for 0.0833333h; Heating;

DOI:10.1002/jhet.5570270449

Reference yield:

2,4-dimethoxy-7H-pyrrolo<2,3-d>pyrimidine (90057-09-3) → 3,4-dihydro-2-methoxy-4-oxo-7H-pyrrolo<2,3-d>pyrimidine (90057-07-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.5h; Heating;

DOI:10.1002/jlac.198419840210

upstream raw materials:

2-chloroethanal

6-amino-2-methoxy-3H-4-pyrimidone

ethyl 2-cyano-4,4-diethoxybutyrate

O-methylisourea hemisulfate

Downstream raw materials:

4-Chlor-2-methoxy-7H-pyrrolo<2,3-d>pyrimidin

Refernces

• 1、 Seela,Liman. "ara-7-Desazaxanthosine: A xanthine nucleoside with a stabile N- glycosylic bond". . p. 273 - 282. Retrieved 2007/10/02.