1-(2-Amino-4-hydroxyphenyl)ethanone

Base Information

• Chemical Name: 1-(2-Amino-4-hydroxyphenyl)ethanone
• CAS No.: 90033-64-0
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.16
• DSSTox Substance ID: DTXSID30561255
• Wikidata: Q82444972
• Mol file: 90033-64-0.mol

Synonyms:1-(2-amino-4-hydroxyphenyl)ethanone;90033-64-0;2'-AMINO-4'-HYDROXYACETOPHENONE;1-(2-amino-4-hydroxyphenyl)ethan-1-one;SCHEMBL9256689;DTXSID30561255;AKOS006286775;SB76403;1-(2-azanyl-4-oxidanyl-phenyl)ethanone;CS-0088238;EN300-1296171;A843416

Chemical Property of 1-(2-Amino-4-hydroxyphenyl)ethanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.614
• Boiling Point: 362.039°C at 760 mmHg
• Flash Point: 172.755°C
• Density: 1.242g/cm³
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Amino-4-hydroxy-phenyl)-ethanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C=C(C=C1)O)N

Technology Process of 1-(2-Amino-4-hydroxyphenyl)ethanone

There total 2 articles about 1-(2-Amino-4-hydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-(2-amino-4-methoxyphenyl)ethanone (42465-53-2) → 2-amino-4′-hydroxyacetophenone (90033-64-0)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 22h; Ambient temperature;

DOI:10.1021/jm00124a014

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → 2-amino-4′-hydroxyacetophenone (90033-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) BCl₃, 2) AlCl₃ / 1) CH₂Cl₂, -50 deg C, 30 min, 2a) -50 deg C, 1h, b) rt, 18 h, c)40 deg C, 3 h

2: 63 percent / AlCl₃ / CH₂Cl₂ / 22 h / Ambient temperature

With aluminium trichloride; boron trichloride; In dichloromethane;

DOI:10.1021/jm00124a014

Reference yield: 87.0%

allyl bromide (106-95-6) + 2-amino-4′-hydroxyacetophenone (90033-64-0) → 2-amino-4-prop-2-enoxyacetophenone (118683-99-1)

Guidance literature:

With potassium carbonate; In acetone; for 18h; Heating;

DOI:10.1021/jm00124a014

upstream raw materials:

1-(2-amino-4-methoxyphenyl)ethanone

m-Anisidine

Downstream raw materials:

2-amino-4-prop-2-enoxyacetophenone

2-amino-4-hydroxy-3-prop-2-enylacetophenone

2-amino-4-hydroxy-3-propylacetophenone

4-(4-Acetyl-3-amino-2-propyl-phenoxymethyl)-3-methoxy-benzoic acid

Refernces