Technology Process of 7-Methyl-2,4-octanedione
There total 2 articles about 7-Methyl-2,4-octanedione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
acetic acid methyl ester;
With
sodium hydride;
In
diethyl ether; mineral oil;
Reflux;
5-Methyl-2-hexanone;
In
diethyl ether; mineral oil;
for 8h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; tetrabutylammomium bromide / acetonitrile / 96 h
2.1: triethylamine; triethylsilyl trifluoromethyl sulfonate / dichloromethane / 0.5 h / 0 °C
3.1: toluene / Reflux
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h
4.2: 48 h
5.1: ethanol; (1S)-10-camphorsulfonic acid / 30 h
With
ethanol; (1S)-10-camphorsulfonic acid; tetrabutylammomium bromide; triethylsilyl trifluoromethyl sulfonate; potassium carbonate; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
3.1: Arbuzov Reaction / 4.1: Wittig-Horner olefination;