p-Toluenesulfenylchloride

Base Information

• Chemical Name: p-Toluenesulfenylchloride
• CAS No.: 933-00-6
• Molecular Formula: C7H7 Cl S
• Molecular Weight: 158.652
• Mol file: 933-00-6.mol

Synonyms:Benzenesulfenylchloride, 4-methyl- (9CI); p-Toluenesulfenyl chloride (6CI,7CI,8CI);4-Methylbenzenesulfenyl chloride; 4-Methylphenylsulfenyl chloride;4-Toluenesulfenyl chloride; 4-Tolylsulfenyl chloride; p-Methylbenzenesulfenylchloride; p-Methylphenylsulfenyl chloride; p-Tolylsulfenyl chloride

Chemical Property of p-Toluenesulfenylchloride

Chemical Property:

• Boiling Point: 281℃
• Flash Point: 120℃
• PSA: 25.30000
• Density: 1.20
• LogP: 3.24090

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-Toluenesulfenylchloride

There total 8 articles about p-Toluenesulfenylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di(p-tolyl) disulfide (103-19-5) → p-methylbenzenesulfenyl chloride (933-00-6)

Guidance literature:

With chlorine; In tetrachloromethane; at -78 ℃;

DOI:10.1080/10426509708044221

Reference yield: 90.0%

C7H10S → p-methylbenzenesulfenyl chloride (933-00-6)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at 25 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

DOI:10.1002/asia.201301295

Reference yield: 87.0%

para-thiocresol (106-45-6) → p-methylbenzenesulfenyl chloride (933-00-6)

Guidance literature:

With sulfuryl dichloride; In hexane; at 0 - 20 ℃; for 1.08333h;

DOI:10.1002/asia.201403319

upstream raw materials:

para-thiocresol

di(p-tolyl) disulfide

tetrachloromethane

chlorine

Downstream raw materials:

N-(5-p-tolylmercapto-thiazol-2-yl)-acetamide

di(4-methyl)phenylthiosulfonate

4-tolyl phenyl sulfide

(2-chloro-ethyl)-p-tolyl sulfide

Refernces

• 1、 Zhang, Dongke,Zhang, Jingran,Li, Xiaoxian,Yu, Zhenyang,Li, Yadong,Sun, Fengxia,Du, Yunfei. "Intramolecular Chalcogenylation of Isooxazolines Mediated by PhICl 2and Diorganyl Disulfides or Diselenides". . p. 411 - 420. Retrieved 2021/10/05.
• 2、 Xu, Yi-xiang,Huang, Yun-yuan,Song, Rong-rong,Ren, Yan-liang,Chen, Xin,Zhang, Chao,Mao, Fei,Li, Xiao-kang,Zhu, Jin,Ni, Shuai-shuai,Wan, Jian,Li, Jian. "Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes". . . Retrieved 2020/07/25.