ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate

Base Information

• Chemical Name: ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate
• CAS No.: 129374-50-1
• Molecular Formula: C₂₂H₂₄N₂O₃
• Molecular Weight: 364.444
• Mol file: 129374-50-1.mol

Synonyms:ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate

Chemical Property of ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate

There total 3 articles about ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-amino-2-pentenoate (129374-49-8) → ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate (129374-50-1)

Guidance literature:

With hydrogenchloride; bromocresol green; sodium cyanoborohydride; In tetrahydrofuran; ethanol; at 0 ℃;

Reference yield:

3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid (21256-18-8) → ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate (129374-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) carbonyldiimidazole / 1.) THF, 25 deg C, 6 h, 2.) 25 deg C

2: 80 percent / ammonium acetate, acetic acid / benzene / 3 h / Heating

3: 87 percent / concd. HCl, NaBH₃CN, Bromokresol Green / tetrahydrofuran; ethanol / 0 °C

With ammonium acetate; hydrogenchloride; bromocresol green; sodium cyanoborohydride; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; benzene;

Reference yield:

ethyl 5-(4,5-diphenyl-2-oxazolyl)pentan-3-onate (129374-48-7) → ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoate (129374-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / ammonium acetate, acetic acid / benzene / 3 h / Heating

2: 87 percent / concd. HCl, NaBH₃CN, Bromokresol Green / tetrahydrofuran; ethanol / 0 °C

With ammonium acetate; hydrogenchloride; bromocresol green; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; ethanol; benzene;

upstream raw materials:

ethyl 5-(4,5-diphenyl-2-oxazolyl)-3-amino-2-pentenoate

3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid

ethyl 5-(4,5-diphenyl-2-oxazolyl)pentan-3-onate

Downstream raw materials:

5-(4,5-diphenyl-2-oxazolyl)-3-aminopentanoic acid

2-<2-(4,5-diphenyl-2-oxazolyl)ethyl>-1-(methoxycarbonylmethyl)azetidinone

{2-[2-(4,5-Diphenyl-oxazol-2-yl)-ethyl]-4-oxo-azetidin-1-yl}-acetic acid allyl ester

2-<2-(4,5-diphenyl-2-oxazolyl)ethyl>-1-(N-allylcarbamoylmethyl)azetidinone

Refernces