N₂-benzyloxycarbonyl-l-glutamine ethyl ester

Base Information

• Chemical Name: N₂-benzyloxycarbonyl-l-glutamine ethyl ester
• CAS No.: 4668-41-1
• Molecular Formula: C₁₅H₂₀N₂O₅
• Molecular Weight: 308.334
• Mol file: 4668-41-1.mol

Synonyms:N₂-benzyloxycarbonyl-l-glutamine ethyl ester

Chemical Property of N₂-benzyloxycarbonyl-l-glutamine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-benzyloxycarbonyl-l-glutamine ethyl ester

There total 5 articles about N₂-benzyloxycarbonyl-l-glutamine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Cbz-L-Gln (2650-64-8) + ethyl iodide (75-03-6) → N2-benzyloxycarbonyl-l-glutamine ethyl ester (4668-41-1)

Guidance literature:

Cbz-L-Gln; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

ethyl iodide; In N,N-dimethyl-formamide; for 97h; Inert atmosphere;

Reference yield: 89.0%

ethanol (64-17-5) + Nα-benzyloxycarbonyl-glutamine (50516-14-8) → N-carbobenzoxy-D-glutamine (13139-52-1) + N2-benzyloxycarbonyl-l-glutamine ethyl ester (4668-41-1)

Guidance literature:

With citrate buffer; DL-cysteine hydrochloride; papain; at 50 ℃; for 24h;

Reference yield:

ethanol (64-17-5) + Cbz-L-Gln (2650-64-8) → N2-benzyloxycarbonyl-l-glutamine ethyl ester (4668-41-1)

Guidance literature:

With thionyl chloride;

DOI:10.1246/bcsj.36.25

upstream raw materials:

ethanol

Nα-benzyloxycarbonyl-glutamine

Cbz-L-Gln

L-glutamine

Downstream raw materials:

(S)-ethyl 2-(benzyloxycarbonylamino)-5-((S)-1-ethoxy-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoate

(S)-6-amino-3-[(benzyloxycarbonyl)(methyl)amino]-2,3,4,5-tetrahydropyridin-2-one

5-benzyloxycarbonylimino-1-methyl-L-proline amide

C₂₃H₂₄N₄O₆

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR PROTECTING CELLS FROM TOXIC EXPOSURES". . . Retrieved 2008/12/04.
• 2、 Moriniere, J. L.,Danree, B.,Lemoine, J.,Guy, A.. "PAPAIN-ASSISTED RESOLUTION OF NATURAL AND XENOBIOTIC α-AMINO ACIDS". . p. 441 - 444. Retrieved 2007/10/02.