(R)-VAPOL HYDROGENPHOSPHATE

Base Information

• Chemical Name: (R)-VAPOL HYDROGENPHOSPHATE
• CAS No.: 871130-18-6
• Molecular Formula: C₄₀H₂₅O₄P
• Molecular Weight: 600.61
• Hs Code.: 29349990
• Mol file: 871130-18-6.mol

Synonyms:VAPOL hydrogenphosphate; VAPOL phosphoric acid; rac-VAPOL hydrogen phosphate; (S)-VAPOL hydrogenphosphate; (R)-VAPOL HYDROGENPHOSPHATE; (R)-VAPOL phosphoric acid; (S)-VAPOL phosphoric acid; 查看更多英文别名 收起

Chemical Property of (R)-VAPOL HYDROGENPHOSPHATE

Chemical Property:

• Melting Point: >300 °C
• PKA: 1.13±0.20(Predicted)
• PSA: 65.57000
• Density: 1.449 g/cm³
• LogP: 11.17200

Purity/Quality:

98%,99%, ^*data from raw suppliers

^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Catalyst involved in:Desymmetrization of meso-aziridinesAsymmetric aza-Darzens aziridine synthesisEnantioselective ring-opening of mono-and bicyclic N-acyl meso aziridinesCondensation of aldehydes with amino benzenesulfonamidesPictet-Spengler reactions

Technology Process of (R)-VAPOL HYDROGENPHOSPHATE

There total 6 articles about (R)-VAPOL HYDROGENPHOSPHATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetylene (536-74-3) → rac-VAPOL hydrogen phosphate (175223-69-5,871130-17-5,871130-18-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) Ac₂O, Et₃N, 3.) AlCl₃, EtSH

2: 89 percent / air / 34 h / 190 °C

3: 1.) POCl₃, pyridine, 2.) H₂O, 3.) 6 N aq. HCl

With pyridine; hydrogenchloride; aluminium trichloride; air; water; acetic anhydride; triethylamine; ethanethiol; trichlorophosphate;

DOI:10.1021/ja952018t

Reference yield:

Acetic acid 4-methoxy-2-phenyl-phenanthren-1-yl ester (175223-47-9) → rac-VAPOL hydrogen phosphate (175223-69-5,871130-17-5,871130-18-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / AlCl₃, EtSH / CH₂Cl₂ / 4.5 h / 25 °C

2: 89 percent / air / 34 h / 190 °C

3: 1.) POCl₃, pyridine, 2.) H₂O, 3.) 6 N aq. HCl

With pyridine; hydrogenchloride; aluminium trichloride; air; water; ethanethiol; trichlorophosphate; In dichloromethane;

DOI:10.1021/ja952018t

Reference yield:

rac-2,2'-diphenyl-[3,3'-biphenanthrene]-4,4'-diol (147702-15-6,147702-16-7,200810-26-0) → rac-VAPOL hydrogen phosphate (175223-69-5,871130-17-5,871130-18-6)

Guidance literature:

With pyridine; hydrogenchloride; water; trichlorophosphate; Yield given. Multistep reaction;

DOI:10.1021/ja952018t

upstream raw materials:

rac-2,2'-diphenyl-[3,3'-biphenanthrene]-4,4'-diol

phenylacetylene

2-phenyl-4-phenanthrol

Acetic acid 4-methoxy-2-phenyl-phenanthren-1-yl ester

Refernces