TERT-BUTYL 4-AMINO-4-(AMINOMETHYL)PIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-AMINO-4-(AMINOMETHYL)PIPERIDINE-1-CARBOXYLATE
• CAS No.: 871115-32-1
• Molecular Formula: C11H23 N3 O2
• Molecular Weight: 229.323
• Hs Code.: 2933399090
• Mol file: 871115-32-1.mol

Synonyms:4-Amino-4-aminomethylpiperidine-1-carboxylicacid tert-butyl ester

Chemical Property of TERT-BUTYL 4-AMINO-4-(AMINOMETHYL)PIPERIDINE-1-CARBOXYLATE

Chemical Property:

• Boiling Point: 326.4±27.0 °C(Predicted)
• PKA: 10.13±0.29(Predicted)
• PSA: 81.58000
• Density: 1.064±0.06 g/cm3(Predicted)
• LogP: 2.01200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl 4-amino-4-(aminomethyl)-piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-AMINO-4-(AMINOMETHYL)PIPERIDINE-1-CARBOXYLATE

There total 6 articles about TERT-BUTYL 4-AMINO-4-(AMINOMETHYL)PIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-aminomethyl-4-(2,2,2-trifluoroacetylamino)piperidine-1-carboxylic acid tert-butyl ester (871115-22-9) → 4-amino-4-aminomethylpiperidine-1-carboxylic acid tert-butyl ester (871115-32-1)

Guidance literature:

With water; potassium carbonate; In methanol; Heating / reflux;

Reference yield:

4-amino-4-cyano-piperidine-1-carboxylic acid tert-butyl ester (331281-25-5) → 4-amino-4-aminomethylpiperidine-1-carboxylic acid tert-butyl ester (871115-32-1) + 4-cyano-4-(2,2,2-trifluoroacetylamino)piperidine-1-carboxylic acid tert-butyl ester (871115-20-7)

Guidance literature:

With trifluoroacetic anhydride; In pyridine; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; Petroleum ether;

Reference yield:

4-amino-4-cyano-piperidine-1-carboxylic acid tert-butyl ester (331281-25-5) → 4-amino-4-aminomethylpiperidine-1-carboxylic acid tert-butyl ester (871115-32-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / methanol / 18 h / 0 °C

2: H₂ / Raney-Ni / ethanol / 18 h / 20 °C

3: 88 percent / pyridine / 18 h / 0 °C

4: NH₃ / methanol / 18 h / Heating

With pyridine; ammonia; hydrogen; nickel; In methanol; ethanol;

DOI:10.1016/j.bmcl.2006.12.026

upstream raw materials:

4-(2,2,2-trifluoroacetylamino)-4-[(2,2,2-trifluoroacetylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester

4-amino-4-cyano-piperidine-1-carboxylic acid tert-butyl ester

4-cyano-4-(2,2,2-trifluoroacetylamino)piperidine-1-carboxylic acid tert-butyl ester

4-aminomethyl-4-(2,2,2-trifluoroacetylamino)piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES". . . Retrieved 2012/04/23.
• 2、 Kim, In Ho,Combrink, Keith D.,Ma, Zhenkun,Chapo, Katrina,Yan, Dalai,Renick, Paul,Morris, Timothy W.,Pulse, Mark,Simecka, Jerry W.,Ding, Charles Z.. "Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins". . p. 1181 - 1184. Retrieved 2007/10/03.