Technology Process of 2-Quinazolinecarboxylic acid, 1,4-dihydro-8-methoxy-4-oxo-, ethyl ester (9CI)
There total 3 articles about 2-Quinazolinecarboxylic acid, 1,4-dihydro-8-methoxy-4-oxo-, ethyl ester (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloro-trimethyl-silane; triethylamine;
In
1,2-dichloro-ethane;
at 20 ℃;
Reflux;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bis(trichloromethyl) carbonate / tetrahydrofuran / 15 h / 60 °C
1.2: 2 h / 60 °C
2.1: triethylamine / tetrahydrofuran / 2 h / 35 °C / Cooling with ice
3.1: sodium ethanolate / ethanol / 1 h / 35 °C / Cooling with ice
With
bis(trichloromethyl) carbonate; sodium ethanolate; triethylamine;
In
tetrahydrofuran; ethanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 2 h / 35 °C / Cooling with ice
2: sodium ethanolate / ethanol / 1 h / 35 °C / Cooling with ice
With
sodium ethanolate; triethylamine;
In
tetrahydrofuran; ethanol;