Technology Process of (2S,3R)-3-(4-fluorophenyl)-4-[(1R)-1-phenylethyl]-2-morpholinol
There total 7 articles about (2S,3R)-3-(4-fluorophenyl)-4-[(1R)-1-phenylethyl]-2-morpholinol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
water; toluene;
at 20 ℃;
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
tetrahydrofuran; toluene;
at -20 ℃;
for 0.5h;
DOI:10.1021/jo0203793
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride / ethyl acetate; water / 1 h / 20 °C
2: sodium hydroxide; water / methanol / 2 h / 20 - 25 °C
3: acetic acid / Isopropyl acetate / 3 h / Reflux; Inert atmosphere
4: hydrogenchloride / 70 - 75 °C
5: sodium hydrogencarbonate / water; toluene / 20 °C
With
hydrogenchloride; water; sodium hydrogencarbonate; acetic acid; sodium hydroxide;
In
methanol; Isopropyl acetate; water; ethyl acetate; toluene;