2-Morpholino-5-(trifluoromethyl)benzoic acid

Base Information

• Chemical Name: 2-Morpholino-5-(trifluoromethyl)benzoic acid
• CAS No.: 865471-20-1
• Molecular Formula: C12H12 F3 N O3
• Molecular Weight: 275.227
• Hs Code.: 2934999090
• Mol file: 865471-20-1.mol

Synonyms:2-(Morpholin-4-yl)-5-trifluoromethylbenzoicacid

Chemical Property of 2-Morpholino-5-(trifluoromethyl)benzoic acid

Chemical Property:

• Melting Point: 175 °C
• PSA: 49.77000
• LogP: 2.30520

Purity/Quality:

99% ^*data from raw suppliers

2-Morpholino-5-(trifluoromethyl)benzoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Morpholino-5-(trifluoromethyl)benzoic acid

There total 1 articles about 2-Morpholino-5-(trifluoromethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

morpholine (110-91-8,99108-56-2) + 2-fluoro-5-(trifluoromethyl)benzoic acid (115029-23-7) → 2-morpholino-5-(trifluoromethyl)benzoic acid (865471-20-1)

Guidance literature:

In 1,4-dioxane; Reflux;

DOI:10.1016/j.ejmech.2021.113316

Reference yield:

2-morpholino-5-(trifluoromethyl)benzoic acid (865471-20-1) + C14H25NO2Si → C26H35F3N2O4Si

Guidance literature:

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h;

DOI:10.1016/j.ejmech.2021.113316

Reference yield:

1-(3-fluoro-4-(piperazine-1-yl)phenyl)ethane-1-one (189763-57-3) + 2-morpholino-5-(trifluoromethyl)benzoic acid (865471-20-1) → C24H25F4N3O3 (1079816-94-6)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2008.07.086

upstream raw materials:

morpholine

2-fluoro-5-(trifluoromethyl)benzoic acid

Downstream raw materials:

C₂₄H₂₅F₄N₃O₃

Refernces

• 1、 Pinard, Emmanuel,Alberati, Daniela,Borroni, Edilio,Fischer, Holger,Hainzl, Dominik,Jolidon, Synese,Moreau, Jean-Luc,Narquizian, Robert,Nettekoven, Matthias,Norcross, Roger D.,Stalder, Henri,Thomas, Andrew W.. "Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors". scheme or table. p. 5134 - 5139. Retrieved 2009/05/26.