Technology Process of N-(2-methoxyethyl)-5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide
There total 8 articles about N-(2-methoxyethyl)-5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine;
With
hexamethyldistannane;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane;
at 20 ℃;
for 16h;
Inert atmosphere;
5-bromo-N-(2-methoxyethyl)pyridine-3-sulfonamide;
In
1,4-dioxane;
at 100 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 40 h / Reflux
2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C
3.1: triethylamine / tetrahydrofuran / 14 h / 20 °C
4.1: hexamethyldistannane / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere
4.2: 16 h / 100 °C / Inert atmosphere
With
hexamethyldistannane; sodium hydrogencarbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C
1.2: pH 4 - 5
2.1: acetic acid / water / 35 °C
3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 40 h / Reflux
4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C
5.1: triethylamine / tetrahydrofuran / 14 h / 20 °C
6.1: hexamethyldistannane / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere
6.2: 16 h / 100 °C / Inert atmosphere
With
dihydrogen peroxide; hexamethyldistannane; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; sodium hydroxide; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water;