4-(4-CHLOROPHENYL)PYRROLIDINE-3-METHYLCARBOXYLATE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(4-CHLOROPHENYL)PYRROLIDINE-3-METHYLCARBOXYLATE HYDROCHLORIDE
• CAS No.: 862283-71-4
• Molecular Formula: C12H14 Cl N O2 . Cl H
• Molecular Weight: 276.163
• Mol file: 862283-71-4.mol

Synonyms:3-Pyrrolidinecarboxylicacid, 4-(4-chlorophenyl)-, methyl ester, hydrochloride, (3S,4R)- (9CI); Methyl(3S,4R)-4-(4-chlorophenyl)pyrrolidine-3-carboxylate hydrochloride

Chemical Property of 4-(4-CHLOROPHENYL)PYRROLIDINE-3-METHYLCARBOXYLATE HYDROCHLORIDE

Chemical Property:

• PSA: 38.33000
• LogP: 2.94680

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3S,4R)-Methyl4-(4-chlorophenyl)pyrrolidine-3-carboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-CHLOROPHENYL)PYRROLIDINE-3-METHYLCARBOXYLATE HYDROCHLORIDE

There total 1 articles about 4-(4-CHLOROPHENYL)PYRROLIDINE-3-METHYLCARBOXYLATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3S,4R)-methyl 1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylate (862283-69-0) → (3S,4R)-methyl 4-(4-chlorophenyl)pyrrolidine-3-carboxylate hydrochloride (862283-71-4,1630945-13-9,1807941-55-4)

Guidance literature:

(3S,4R)-methyl 1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylate; With carbonochloridic acid 1-chloro-ethyl ester; In toluene; at 20 ℃; for 3.5h;

With hydrogenchloride; In toluene;

DOI:10.1021/jm5011397

Reference yield: 77.0%

(3S,4R)-methyl 4-(4-chlorophenyl)pyrrolidine-3-carboxylate hydrochloride (862283-71-4,1630945-13-9,1807941-55-4) + (R)-3-(tert-butoxycarbonylamino)-4-(4-chlorophenyl)butanoic acid (218608-96-9,1824131-52-3) → (3S,4R)-methyl 1-((R)-3-((tert-butoxycarbonyl)amino)-4-(4-chlorophenyl)butanoyl)-4-(4-chlorophenyl)pyrrolidine-3-carboxylate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3.5h;

DOI:10.1021/jm5011397

upstream raw materials:

(3S,4R)-methyl 1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylate

Refernces

• 1、 -. "Pharmaceutically active compounds". Page/Page column 63. . Retrieved 2010/02/13.