Technology Process of (Z)-6-phenyl-5-hexenal
There total 11 articles about (Z)-6-phenyl-5-hexenal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dichloromethane; dimethyl sulfoxide;
at 50 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201007751
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / n-BuLi, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1.5 h
2: 76 percent / H2, quinoline / Pd-CaCO3 / methanol / 10 h / 760 Torr
3: 98.7 percent / aq. p-toluenesulfonic acid / methanol / 1 h / 60 °C
4: 85 percent / pyridinium chlorochromate, sodium acetate / CH2Cl2 / 2 h
With
quinoline; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; hydrogen; sodium acetate; toluene-4-sulfonic acid; pyridinium chlorochromate;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1246/bcsj.72.73
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) NaH, DMSO / 1.) 75 deg C, 30 min, 2.) DMSO, 75 deg C, 1 h
2: 1.) (COCl)2, 2.) Et3N / 1.) CH2Cl2, DMSO, -60 deg C, 30 min, 2.) CH2Cl2, DMSO, -60 deg C to RT
With
oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine;
DOI:10.1021/ja00019a038
