N,N-dihexadecyl-N^α-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide

Base Information

• Chemical Name: N,N-dihexadecyl-N^α-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide
• CAS No.: 748818-26-0
• Molecular Formula: C₄₉H₈₈N₂O₅
• Molecular Weight: 785.248
• Mol file: 748818-26-0.mol

Synonyms:N,N-dihexadecyl-N^α-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide

Chemical Property of N,N-dihexadecyl-N^α-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dihexadecyl-N^α-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide

There total 1 articles about N,N-dihexadecyl-N^α-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

dihexadecylamine (16724-63-3) + Boc-Glu(OBzl)-OH (13574-13-5) → N,N-dihexadecyl-Nα-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide (748818-26-0)

Guidance literature:

Boc-Glu(OBzl)-OH; With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.5h;

dihexadecylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ja053226g

Reference yield:

N,N-dihexadecyl-Nα-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide (748818-26-0) → (S)-4-Amino-4-dihexadecylcarbamoyl-butyric acid benzyl ester

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja053226g

Reference yield:

N,N-dihexadecyl-Nα-tert-butoxycarbonyl-O-benzyl-L-glutamic acid α-amide (748818-26-0) → N,N-dihexadecyl-Nα-6-bromohexanoyl-O-benzyl-L-glutamic acid α-amide (864846-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

2: 0.205 g / CH₂Cl₂ / 0 °C

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja053226g

upstream raw materials:

dihexadecylamine

Boc-Glu(OBzl)-OH

Downstream raw materials:

N,N-dihexadecyl-N^α-6-bromohexanoyl-O-benzyl-L-glutamic acid α-amide

Refernces